Document Detail

Higher habitual sodium intake is not detrimental for bones in older women with adequate calcium intake.
MedLine Citation:
PMID:  20217116     Owner:  NLM     Status:  MEDLINE    
Based on the calciuric effect of sodium (Na), it has been speculated, although not proven, that higher Na intake might have a detrimental effect on bone health. The objective was to determine the relationship between Na intake (expressed as urinary Na) and bone mineral density/content (BMD/BMC) during a 3-year study. Participants were healthy, postmenopausal, Caucasian women (n = 136 at baseline) with no medications affecting bone. After baseline screening, half were instructed to reduce sodium intake to approximately 1,500 mg/day (intervention). The other half remained on habitual intake of approximately 3,000 mg/day (control). All subjects were given calcium and vitamin D supplements to achieve recommended levels. Anthropometries, densitometry, blood and 24-h urine analyses, and dietary and activity records were assessed every 6 months. Data were analyzed as a continuum, irrespective of the initial assignment to a control or intervention group, using random effects regressions with repeated measures analysis of variance to examine changes over time. Results showed that subjects with higher Na intake had higher BMD in the forearm and spine at baseline and all subsequent time-points (p < 0.01). In the forearm, time and higher urinary calcium modified results, producing a curvilinear decrease in BMD (p < 0.01). In the spine, more active individuals had higher BMD at all time-points. We conclude that higher sodium intake, within the range consumed, had a positive effect on some skeletal sites and no adverse effect on bone in women who had adequate calcium and vitamin D intake.
Jasminka Z Ilich; Rhonda A Brownbill; Daniel C Coster
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-03-10
Journal Detail:
Title:  European journal of applied physiology     Volume:  109     ISSN:  1439-6327     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  745-55     Citation Subset:  IM    
Nutrition, Food and Exercise Sciences, Florida State University, 120 Convocation Rd, 418 Sandels Bldg., Tallahassee, FL 32303-1493, USA.
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MeSH Terms
Absorptiometry, Photon
Age Factors
Aged, 80 and over
Biological Markers / blood,  urine
Bone Density*
Calcium / urine
Calcium, Dietary / administration & dosage*,  metabolism
Dietary Supplements*
European Continental Ancestry Group
Femur / metabolism,  radiography
Longitudinal Studies
Lumbar Vertebrae / metabolism,  radiography
Middle Aged
Nutrition Policy
Nutritional Status
Radius / metabolism,  radiography
Sodium / urine
Sodium Chloride, Dietary / administration & dosage*,  adverse effects,  metabolism
Time Factors
United States
Vitamin D / administration & dosage,  metabolism
Women's Health
Reg. No./Substance:
0/Biological Markers; 0/Calcium, Dietary; 0/Sodium Chloride, Dietary; 1406-16-2/Vitamin D; 7440-23-5/Sodium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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