Document Detail

Higher frequency of screening TSH above 5 mIU/l in infants likely exposed to higher doses of iodine-containing skin antiseptic: implications for assessment of iodine sufficiency.
MedLine Citation:
PMID:  19554807     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Neonatal TSH screening has as its main goal the early detection and treatment of permanent sporadic congenital hypothyroidism. At the same time neonatal TSH is one of the indicators for monitoring progress towards eliminating iodine deficiency disorders (IDD).
AIM: To evaluate the usefulness of neonatal TSH screening data as a monitoring tool for IDD evaluation and control in Bosnia and Herzegovina.
INFANTS AND METHODS: The study included a total of 8,105 newborns. Neonatal TSH was measured in whole blood drawn between day 3 and day 5 of life, spotted on filter paper using a sensitive fluorometric assay (Delfia).
RESULTS: Levels above 5 mIU/l were found in 282 (5.5%) neonates. Median TSH values and the percentage of samples of neonatal TSH above 5 mIU/l were significantly higher in neonates who were born by Caesarean section (6.4%) compared with neonates born by vaginal delivery (1.4%).
CONCLUSION: Our findings suggest that neonatal TSH should not be used as a monitoring tool for IDD evaluation and control if iodinated skin disinfectant is used on a large part of the mother's skin in maternity hospitals.
H Tahirovic; A Toromanovic; S Grbic
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  22     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-06-26     Completed Date:  2009-07-09     Revised Date:  2011-08-25    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  335-8     Citation Subset:  IM    
Department of Pediatrics, University Clinical Center, Tuzla, Bosnia and Herzegovina.
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MeSH Terms
Anti-Infective Agents, Local / adverse effects*,  contraindications
Cesarean Section
Congenital Hypothyroidism / diagnosis*
Deficiency Diseases / diagnosis
Delivery, Obstetric
Infant, Newborn / blood*
Iodides / adverse effects*
Iodine / adverse effects*,  contraindications,  deficiency
Neonatal Screening
Thyrotropin / blood*
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Iodides; 7553-56-2/Iodine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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