Document Detail


Higher frequency of screening TSH above 5 mIU/l in infants likely exposed to higher doses of iodine-containing skin antiseptic: implications for assessment of iodine sufficiency.
MedLine Citation:
PMID:  19554807     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Neonatal TSH screening has as its main goal the early detection and treatment of permanent sporadic congenital hypothyroidism. At the same time neonatal TSH is one of the indicators for monitoring progress towards eliminating iodine deficiency disorders (IDD).
AIM: To evaluate the usefulness of neonatal TSH screening data as a monitoring tool for IDD evaluation and control in Bosnia and Herzegovina.
INFANTS AND METHODS: The study included a total of 8,105 newborns. Neonatal TSH was measured in whole blood drawn between day 3 and day 5 of life, spotted on filter paper using a sensitive fluorometric assay (Delfia).
RESULTS: Levels above 5 mIU/l were found in 282 (5.5%) neonates. Median TSH values and the percentage of samples of neonatal TSH above 5 mIU/l were significantly higher in neonates who were born by Caesarean section (6.4%) compared with neonates born by vaginal delivery (1.4%).
CONCLUSION: Our findings suggest that neonatal TSH should not be used as a monitoring tool for IDD evaluation and control if iodinated skin disinfectant is used on a large part of the mother's skin in maternity hospitals.
Authors:
H Tahirovic; A Toromanovic; S Grbic
Related Documents :
9109607 - Infant survival is improved by oral iodine supplementation.
3196047 - Increased recall rate at screening for congenital hypothyroidism in breast fed infants ...
11332167 - Antenatal magnesium sulphate exposure is associated with prolonged parathyroid hormone ...
6231357 - Abnormalities of thyroid function in infants with down syndrome.
4072007 - Infant astigmatism and meridional amblyopia.
10361517 - Chronic peripheral separation of placenta. the significance of diffuse chorioamnionic h...
Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  22     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-06-26     Completed Date:  2009-07-09     Revised Date:  2011-08-25    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  335-8     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University Clinical Center, Tuzla, Bosnia and Herzegovina. husref.tahirovic@untz.ba
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anti-Infective Agents, Local / adverse effects*,  contraindications
Bosnia-Herzegovina
Cesarean Section
Congenital Hypothyroidism / diagnosis*
Deficiency Diseases / diagnosis
Delivery, Obstetric
Humans
Infant, Newborn / blood*
Iodides / adverse effects*
Iodine / adverse effects*,  contraindications,  deficiency
Neonatal Screening
Parturition
Thyrotropin / blood*
Chemical
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Iodides; 7553-56-2/Iodine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Excessive iodine intake and ultrasonographic thyroid abnormalities in schoolchildren.
Next Document:  Evolution of sonographic appearance of the thyroid gland in children with Hashimoto's thyroiditis.