Document Detail


Higher expression of alpha7 nicotinic acetylcholine receptors in human fetal compared to adult brain.
MedLine Citation:
PMID:  12711366     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neuronal nicotinic acetylcholine receptors are thought to be involved in regulation of several processes during neurogenesis of the brain. In this study the expression of the alpha7 nicotinic acetylcholine receptor subtype was investigated in human fetal (9-11 weeks of gestation), middle-aged (28-51 years) and aged (68-94 years) medulla oblongata, pons, frontal cortex, and cerebellum. The specific binding of the alpha7 receptor antagonist [(125)I]alpha-bungarotoxin was significantly higher in fetal than in both middle-aged and aged medulla oblongata and aged pons. No significant decrease in [(125)I]alpha-bungarotoxin binding sites was observed from fetal to adult cortex and cerebellum. The alpha7 mRNA expression was significantly higher in all fetal brain regions investigated, except for aged cortex, than in corresponding middle-aged and aged tissue. The high expression of alpha7 nicotinic acetylcholine receptors in fetal compared to adult brain supports the view that these receptors play an important role during brain development.
Authors:
Lena Falk; Agneta Nordberg; Ake Seiger; Anders Kjaeldgaard; Ewa Hellstr?m-Lindahl
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research. Developmental brain research     Volume:  142     ISSN:  0165-3806     ISO Abbreviation:  Brain Res. Dev. Brain Res.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-04-24     Completed Date:  2003-08-01     Revised Date:  2010-06-04    
Medline Journal Info:
Nlm Unique ID:  8908639     Medline TA:  Brain Res Dev Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  151-60     Citation Subset:  IM    
Affiliation:
Neurotec Department, Division of Molecular Neuropharmacology, Huddinge University Hospital, S-141 86, Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Aging / genetics,  metabolism
Binding Sites / genetics
Binding, Competitive / drug effects,  genetics
Brain / cytology,  embryology*,  metabolism*
Bungarotoxins / diagnostic use
Cell Differentiation / genetics*
Cyclophilins / genetics
Female
Fetus
Gene Expression Regulation, Developmental / genetics
Humans
Iodine Radioisotopes / diagnostic use
Male
Middle Aged
Neurons / cytology,  metabolism*
Postmortem Changes
RNA, Messenger / metabolism
Radioligand Assay
Receptors, Nicotinic / genetics*
Stem Cells / cytology,  metabolism*
Up-Regulation / genetics*
Chemical
Reg. No./Substance:
0/Bungarotoxins; 0/Iodine Radioisotopes; 0/RNA, Messenger; 0/Receptors, Nicotinic; 0/alpha7 nicotinic acetylcholine receptor; EC 5.2.1.-/Cyclophilins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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