Document Detail


Higher dietary lycopene intake is associated with longer cardiac event-free survival in patients with heart failure.
MedLine Citation:
PMID:  23076979     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The antioxidant lycopene may be beneficial for patients with heart failure (HF). Processed tomato products are a major source of lycopene, although they are also high in sodium. Increased sodium intake may counter the positive antioxidant effect of lycopene.
METHODS: This was a prospective study of 212 patients with HF. Dietary intake of lycopene and sodium was obtained from weighted 4-day food diaries. Patients were grouped by the median split of lycopene of 2471 µg/day and stratified by daily sodium levels above and below 3 g/day. Patients were followed for 1 year to collect survival and hospitalization data. Cox proportional hazards modeling was used to compare cardiac event-free survival between lycopene groups within each stratum of sodium intake.
RESULTS: Higher lycopene intake was associated with longer cardiac event-free survival compared with lower lycopene intake (p = 0.003). The worst cardiac event-free survival was observed in the low lycopene intake group regardless of sodium intake (> 3 g/day HR = 3.01; p = 0.027 and ≤ 3 g/day HR= 3.34; p = 0.023).
CONCLUSION: These findings suggest that increased lycopene intake has the potential to improve cardiac event-free survival in patients with HF independent of sodium intake.
Authors:
Martha Biddle; Debra Moser; Eun Kyeung Song; Seongkum Heo; Heather Payne-Emerson; Sandra B Dunbar; Susan Pressler; Terry Lennie
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-10-16
Journal Detail:
Title:  European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology     Volume:  12     ISSN:  1873-1953     ISO Abbreviation:  Eur J Cardiovasc Nurs     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-26     Completed Date:  2014-03-10     Revised Date:  2014-06-16    
Medline Journal Info:
Nlm Unique ID:  101128793     Medline TA:  Eur J Cardiovasc Nurs     Country:  England    
Other Details:
Languages:  eng     Pagination:  377-84     Citation Subset:  IM; N    
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MeSH Terms
Descriptor/Qualifier:
Aged
Antioxidants* / administration & dosage
Carotenoids* / administration & dosage
Diet Records
Disease-Free Survival
Female
Heart Failure / diet therapy*,  mortality
Hospitalization
Humans
Longitudinal Studies
Male
Middle Aged
Proportional Hazards Models
Prospective Studies
Sodium, Dietary
Grant Support
ID/Acronym/Agency:
1P20 NR 010679/NR/NINR NIH HHS; 3R01 NR 009280/NR/NINR NIH HHS; M01 RR000034/RR/NCRR NIH HHS; P20 NR010679/NR/NINR NIH HHS; R01 NR009280/NR/NINR NIH HHS; UL1 TR000117/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Sodium, Dietary; 36-88-4/Carotenoids; SB0N2N0WV6/lycopene

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