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Higher dietary lycopene intake is associated with longer cardiac event-free survival in patients with heart failure.
MedLine Citation:
PMID:  23076979     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: The antioxidant lycopene may be beneficial for patients with heart failure (HF). Processed tomato products are a major source of lycopene, although they are also high in sodium. Increased sodium intake may counter the positive antioxidant effect of lycopene. METHODS: This was a prospective study of 212 patients with HF. Dietary intake of lycopene and sodium was obtained from weighted 4-day food diaries. Patients were grouped by the median split of lycopene of 2471 µg/day and stratified by daily sodium levels above and below 3 g/day. Patients were followed for 1 year to collect survival and hospitalization data. Cox proportional hazards modeling was used to compare cardiac event-free survival between lycopene groups within each stratum of sodium intake. RESULTS: Higher lycopene intake was associated with longer cardiac event-free survival compared with lower lycopene intake (p = 0.003). The worst cardiac event-free survival was observed in the low lycopene intake group regardless of sodium intake (> 3 g/day HR = 3.01; p = 0.027 and ≤ 3 g/day HR= 3.34; p = 0.023). CONCLUSION: These findings suggest that increased lycopene intake has the potential to improve cardiac event-free survival in patients with HF independent of sodium intake.
Authors:
Martha Biddle; Debra Moser; Eun Kyeung Song; Seongkum Heo; Heather Payne-Emerson; Sandra B Dunbar; Susan Pressler; Terry Lennie
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-16
Journal Detail:
Title:  European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology     Volume:  -     ISSN:  1873-1953     ISO Abbreviation:  Eur J Cardiovasc Nurs     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128793     Medline TA:  Eur J Cardiovasc Nurs     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
College of Nursing, University of Kentucky, USA.
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