| Higher coated-platelet levels are associated with stroke recurrence following nonlacunar brain infarction. | |
| | |
MedLine Citation:
|
PMID: 23149559 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Coated-platelets are procoagulant platelets observed upon dual-agonist stimulation with collagen and thrombin. Coated-platelet levels are elevated in patients with nonlacunar (large-vessel) ischemic stroke and decreased in patients with spontaneous intracerebral hemorrhage as compared with controls. The purpose of this study was to investigate a possible relationship between coated-platelet levels and stroke recurrence in patients with nonlacunar ischemic stroke. We assayed coated-platelet levels in 190 consecutive patients with nonlacunar stroke who were followed for up to 12 months; 20 subjects experienced recurrent stroke. Subjects were categorized into tertiles of coated-platelet levels. The distributions of time-to-recurrent stroke were estimated for each tertile using cumulative incidence curves and compared statistically using a log-rank test. The cumulative incidence of recurrent stroke at 12 months differed among the coated-platelet tertiles: 2% for the first tertile (lowest coated-platelet levels), 18% for the second tertile, and 17% for the third tertile (overall log-rank test, P=0.019). These data suggest that higher levels of coated-platelets, measured shortly after a nonlacunar stroke, are associated with an increased incidence of stroke recurrence. This observation offers an additional tool for identifying patients at highest risk for stroke recurrence following a nonlacunar (large-vessel) infarct. |
| | |
Authors:
|
Calin I Prodan; Julie A Stoner; Linda D Cowan; George L Dale |
Related Documents
:
|
9191089 - Elevated expression of glutathione peroxidase in pc12 cells results in protection again... 9824659 - Hydroxyl radical production in the substantia nigra after 6-hydroxydopamine and hypoxia... 9600659 - Lecithinized superoxide dismutase attenuates phorbol myristate acetate-induced injury i... 2836109 - Does captopril attenuate reperfusion-induced myocardial dysfunction by scavenging free ... 11495009 - Superoxide generation from human polymorphonuclear leukocytes by liposome-encapsulated ... 2169299 - Measurement of reactive oxygen metabolites produced by human monocyte-derived macrophag... 6832159 - Monoclonal antibodies against platelet membrane glycoproteins. characterization and eff... 4041129 - The pathology of the spleen in steroid-treated immune thrombocytopenic purpura. 17585879 - The nmr solution structure of recombinant rgd-hirudin. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2012-11-14 |
Journal Detail:
|
Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 33 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2013 Feb |
Date Detail:
|
Created Date: 2013-02-01 Completed Date: 2013-03-25 Revised Date: 2013-04-16 |
Medline Journal Info:
|
Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
|
Languages: eng Pagination: 287-92 Citation Subset: IM |
Affiliation:
|
Department of Neurology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA. calin-prodan@ouhsc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Blood Platelets / metabolism*, pathology Brain Infarction / blood*, complications, epidemiology Collagen / metabolism Female Follow-Up Studies Humans Incidence Male Middle Aged Platelet Function Tests Stroke / blood*, epidemiology, etiology Thrombin / metabolism |
| Chemical | |
Reg. No./Substance:
|
9007-34-5/Collagen; EC 3.4.21.5/Thrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Critical closing pressure determined with a model of cerebrovascular impedance.
Next Document: In vivo imaging of dopaminergic neurotransmission after transient focal ischemia in rats.