Document Detail

Higher carotid-radial pulse wave velocity in healthy offspring of patients with Type 2 diabetes.
MedLine Citation:
PMID:  15008837     Owner:  NLM     Status:  MEDLINE    
AIMS: To determine whether carotid-radial pulse wave velocity (crPWV), a simple non-invasive measurement of muscular artery structure and function, is increased in offspring of patients with Type 2 diabetes compared with well-matched controls with no family history of diabetes. Serum levels of intercellular adhesion molecule-1 (sICAM-1) were also examined. METHODS: Offspring (n = 19, M = 8) were recruited via contact with patients attending clinics. Controls (n = 19, M = 8) were recruited by advertisement. crPWV was measured using COMPLIOR. Blood pressure and heart rate were determined and fasting blood taken for measurement of metabolic and endothelial parameters. RESULTS: Offspring and controls were well matched [mean (sd)] for age [33.1 (9.6) vs. 32.8 (9.5) years], body mass index [24.8 (4.9) vs. 24.3 (3.4) kg/m2], waist circumference [78.3 (2.3) vs. 76.3 (2.5) cm], and systolic blood pressure [120 (9.3) vs. 119 (14.2) mmHg]. crPWV was 10% higher in the offspring [9.94 (1.3) m/s] compared with controls [9.01 (1.2) m/s, P = 0.02] despite similar pulse pressure [52 (10.5) vs. 53.5 (9.3) mmHg] and resting heart rate [71 (8.7) vs. 69 (14.0) beats/min]. They also showed a trend toward higher sICAM-1 [217 (55) vs. 188 (40) ng/ml, P = 0.07] concentrations which were also strongly correlated to crPWV in offspring (r = 0.63, P = 0.004). CONCLUSIONS: Vascular dysfunction in the form of increased muscular artery stiffness is present from an early stage in subjects at higher risk of developing diabetes. This may be secondary to impaired activation of endothelial signalling pathways in the context of inherited insulin resistance.
O D McEleavy; R W McCallum; J R Petrie; M Small; J M C Connell; N Sattar; S J Cleland
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diabetic medicine : a journal of the British Diabetic Association     Volume:  21     ISSN:  0742-3071     ISO Abbreviation:  Diabet. Med.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-10     Completed Date:  2004-05-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8500858     Medline TA:  Diabet Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  262-6     Citation Subset:  IM    
Division of Cardiovascular & Medical Sciences, University of Glasgow, UK.
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MeSH Terms
Adult Children
Blood Flow Velocity / physiology
Brachial Artery / physiology
Carotid Arteries / physiology*
Diabetes Mellitus, Type 2 / physiopathology*
Diabetic Angiopathies / physiopathology*
Enzyme-Linked Immunosorbent Assay / methods
Family Health
Intercellular Adhesion Molecule-1 / blood
Pulsatile Flow / physiology*
Radial Artery / physiology*
Vascular Cell Adhesion Molecule-1 / blood
Reg. No./Substance:
0/Vascular Cell Adhesion Molecule-1; 126547-89-5/Intercellular Adhesion Molecule-1

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