Document Detail

Higher blood pressure load (baric impact) in normotensives with endothelial dysfunction: a paraphysiological status of "pre-hypertension".
MedLine Citation:
PMID:  12510414     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The present study investigated the blood pressure (BP) load (L), namely Baric Impact (BI), in normotensives with and without endothelial dysfunction (ED). The aim was to detect baric differences supporting the thesis that the ED is associated with vasopressant effects that are responsible for a paraphysiological condition of higher BP (pre-hypertension) even in normotensives. MATERIALS AND METHODS: Thirty-eight normotensives were investigated in their endothelium-dependent vasomotricity by mean of the non-invasive post-ischemic brachial artery vasodilation test. Additionally, their underwent a non-invasive ambulatory (A) BP monitoring (M) over the 24-h span in order to confirm that they were not hypertensive. The ABPM served also to compute the systolic (S) and diastolic (D) BI. RESULTS: The ED was detected in eight normotensives of the investigated group. These cases with ED were found to show a significantly higher SBI and DBI as compared to the normotensives without ED. CONCLUSIONS: The significant elevation of the SBI and DBI in normotensives with ED is an evidence convincing that a dysfunctional endothelium is responsible for vasopressant effects that cause a paraphysiological status of "pre-hypertension".
P Cugini; F Baldoni; R De Rosa; C Pandolfi; M Colotto; P A Buccarella; C Zamparelli; D Berti; B Passini; V Roncoroni; D Sabino; A Capria
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  La Clinica terapeutica     Volume:  153     ISSN:  0009-9074     ISO Abbreviation:  Clin Ter     Publication Date:    2002 Sep-Oct
Date Detail:
Created Date:  2003-01-03     Completed Date:  2003-03-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372604     Medline TA:  Clin Ter     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  309-15     Citation Subset:  IM    
Department of Clinical Sciences, University of Rome La Sapienza, Rome, Italy.
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MeSH Terms
Blood Pressure*
Blood Pressure Monitoring, Ambulatory
Brachial Artery
Circadian Rhythm
Endothelium, Vascular / physiopathology*
Hypertension / diagnosis,  physiopathology*
Middle Aged

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