Document Detail


Higher blood pressure load (baric impact) in normotensives with endothelial dysfunction: a paraphysiological status of "pre-hypertension".
MedLine Citation:
PMID:  12510414     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The present study investigated the blood pressure (BP) load (L), namely Baric Impact (BI), in normotensives with and without endothelial dysfunction (ED). The aim was to detect baric differences supporting the thesis that the ED is associated with vasopressant effects that are responsible for a paraphysiological condition of higher BP (pre-hypertension) even in normotensives. MATERIALS AND METHODS: Thirty-eight normotensives were investigated in their endothelium-dependent vasomotricity by mean of the non-invasive post-ischemic brachial artery vasodilation test. Additionally, their underwent a non-invasive ambulatory (A) BP monitoring (M) over the 24-h span in order to confirm that they were not hypertensive. The ABPM served also to compute the systolic (S) and diastolic (D) BI. RESULTS: The ED was detected in eight normotensives of the investigated group. These cases with ED were found to show a significantly higher SBI and DBI as compared to the normotensives without ED. CONCLUSIONS: The significant elevation of the SBI and DBI in normotensives with ED is an evidence convincing that a dysfunctional endothelium is responsible for vasopressant effects that cause a paraphysiological status of "pre-hypertension".
Authors:
P Cugini; F Baldoni; R De Rosa; C Pandolfi; M Colotto; P A Buccarella; C Zamparelli; D Berti; B Passini; V Roncoroni; D Sabino; A Capria
Related Documents :
17220924 - Sex variations in the haemorheological parameters of some hypertensive nigerians as com...
10206094 - Endothelin plays an important role in the endothelium-dependent vasodilatation in the h...
8695024 - Absence of enhanced sympathoadrenal activity and behaviorally evoked cardiovascular rea...
9402244 - Concomitant evaluation of plasma galanin and catecholamine levels during a cold pressor...
2719144 - Arginine vasopressin mediates cardiovascular responses to hypoxemia in fetal sheep.
8181494 - Diastolic function of the fetal heart during second and third trimester: a prospective ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  La Clinica terapeutica     Volume:  153     ISSN:  0009-9074     ISO Abbreviation:  Clin Ter     Publication Date:    2002 Sep-Oct
Date Detail:
Created Date:  2003-01-03     Completed Date:  2003-03-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372604     Medline TA:  Clin Ter     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  309-15     Citation Subset:  IM    
Affiliation:
Department of Clinical Sciences, University of Rome La Sapienza, Rome, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure*
Blood Pressure Monitoring, Ambulatory
Brachial Artery
Circadian Rhythm
Endothelium, Vascular / physiopathology*
Female
Humans
Hypertension / diagnosis,  physiopathology*
Ischemia
Male
Middle Aged
Vasodilation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Obstacles to the routine discussion with hospital patients of possible cardiopulmonary resuscitation
Next Document:  Effectiveness and safety of montelukast versus budesonide at various doses on bronchial reactivity i...