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Higher allergenicity of high molecular weight hydrolysed wheat protein in cosmetics for percutaneous sensitization.
MedLine Citation:
PMID:  23205470     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background Wheat protein derivatives are used in a variety of products worldwide. Gluten is commercially used 'as is' or with modifications such as hydrolysis, which is carried out to overcome its insolubility. Several cases of contact urticaria following exposure to hydrolysed wheat protein (HWP) in cosmetics or of anaphylaxis caused by deamidated gluten in food or non-food products have been described. Objectives To evaluate the types of HWP that have higher allergenicity for percutaneous sensitization. Methods We enrolled 7 patients with wheat-dependent exercise-induced anaphylaxis who had been sensitized to HWP primarily through the percutaneous and/or the rhinoconjunctival route by using facial soap containing HWP. Reaction to wheat proteins was confirmed by IgE immunoblotting and basophil CD203c expression with six HWP variants. Results The IgE of all the patients reacted to HWPs composed of large polypeptide aggregates. High molecular weight (MW) HWPs were also found to induce significant enhancement of basophil CD203c expression. Conclusions HWPs composed of large polypeptide aggregates possibly induce sensitization to a greater degree than lower-MW HWPs. Basophil surface CD203c expression is useful for evaluating the allergenicity of HWPs.
Authors:
Yuko Chinuki; Hitoshi Takahashi; Itaru Dekio; Sakae Kaneko; Reiko Tokuda; Mizuho Nagao; Takao Fujisawa; Eishin Morita
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-4
Journal Detail:
Title:  Contact dermatitis     Volume:  -     ISSN:  1600-0536     ISO Abbreviation:  Contact Derm.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Affiliation:
Department of Dermatology, Shimane University Faculty of Medicine, Izumo, Shimane 693-8501, Japan Institute for Clinical Research, Mie National Hospital, Tsu, Mie 514-0125, Japan.
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