| Higher urinary excretion of inorganic phosphate during early induction chemotherapy predicts a good prognosis in childhood acute leukemia. | |
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MedLine Citation:
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PMID: 21423043 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The rapidity of response to induction therapy is emerging as an important prognostic factor in children with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Urine inorganic phosphate (IP) and uric acid (UA) may increase in patients with acute leukemia who undergo their induction chemotherapy, owing to the breakdown of tumor cells. The crystallization of UA or calcium phosphate in renal tubules can result in acute tumor lysis syndrome (ATLS). Some reports indicate that patients who experience ATLS have a better prognosis than those who do not. We investigated the relationship between urinary IP and UA excretion and treatment outcome in children with acute leukemia. Participants included 93 patients with ALL and 31 patients with AML. Urine samples were collected and measured for the first 3 days of induction chemotherapy. Among patients with ALL, urinary IP excretion was significantly higher in patients without relapse than in those with relapse and correlated with long-term outcome. Among patients with AML, urinary IP excretion was significantly higher in patients without induction failure (IF) than those with IF. We propose that higher urinary IP excretion could be a useful prognostic marker for determining favorable outcomes in patients with acute leukemia. |
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Authors:
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Mizuho Ichikawa; Ryoji Kobayashi; Masahide Nakajima; Jun Inamoto; Daisuke Suzuki; Yuko Cho; Makoto Kaneda; Makoto Yoshida; Tadashi Ariga |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pediatric hematology/oncology Volume: 33 ISSN: 1536-3678 ISO Abbreviation: J. Pediatr. Hematol. Oncol. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-25 Completed Date: 2011-06-30 Revised Date: 2011-10-06 |
Medline Journal Info:
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Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: e143-8 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan. mizuho@med.hokudai.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Antineoplastic Combined Chemotherapy Protocols / administration & dosage* Biological Markers / urine Child Child, Preschool Female Humans Infant Leukemia, Myeloid, Acute / diagnosis, drug therapy*, urine Male Phosphates / urine* Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis, drug therapy*, urine Predictive Value of Tests Prognosis Recurrence Treatment Outcome Tumor Lysis Syndrome / diagnosis, urine* Uric Acid / urine |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Phosphates; 69-93-2/Uric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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