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Higher Serum Levels of Soluble Intracellular Cell Adhesion Molecule-1 and Soluble Vascular Cell Adhesion Molecule Predict Peripheral Artery Disease in Hemodialysis Patients.
MedLine Citation:
PMID:  22905988     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background:  Serum levels of soluble intracellular cell adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM), and monocyte chemotactic protein 1 (MCP-1), are elevated in patients with peripheral artery disease (PAD). However, the levels of these cell adhesion molecules in patients undergoing hemodialysis (HD) are unclear. Method:  A total of 112 HD patients were included and PAD was diagnosed using the ankle-brachial index and Doppler ultrasound. Serum levels of sICAM-1, sVCAM-1, and MCP-1 were assayed using ELISA. Results:  Out of 106 HD patients, 31 (27.7%) were diagnosed with PAD. After adjusting for risk factors, higher serum levels of sVCAM-1 and sICAM-1 were associated with PAD in HD patients, with an odds ratio of 5.3 (95% CI 3.3-65.5) and 2.7 (95% CI 1.2-21.8) respectively. Using sVCAM-1 and sICAM-1 for diagnosis of PAD in HD patients, sVCAM-1 had a sensitivity of 72.4% and specificity of 62.3% for sVCAM-1 and sICAM-1 had a sensitivity of 89.3% and a specificity of 40%. MCP-1 was not associated with PAD in HD patients. In addition, the fistula of HD patients with PAD had a lower A-V access flow. Conclusion:  sVCAM-1 and sICAM-1 was associated with higher risk of PAD in HD patients. Moreover, HD patients with PAD had a lower blood flow and lower A-V access flow. Our results showed that sVCAM-1 and sICAM-1 may be used as a screening markers for PAD in HD patients. © 2012 The Author. Nephrology © 2012 Asian Pacific Society of Nephrology.
Authors:
Chi-Hung Cheng; Yi-Shyan Chen; Kuo-Hsiung Shu; Horng-Rong Chang; Ming-Chih Chou
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-21
Journal Detail:
Title:  Nephrology (Carlton, Vic.)     Volume:  -     ISSN:  1440-1797     ISO Abbreviation:  Nephrology (Carlton)     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9615568     Medline TA:  Nephrology (Carlton)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Nephrology © 2012 Asian Pacific Society of Nephrology.
Affiliation:
Institute of Medicine, Chung Shun Medical University, Taichung, Taiwan. Department of Nephrology, Taichung Veterans General Hospital, Taichung, Taiwan. Department of Biotechnology, Hung Kuang University, Taichung, Taiwan. College of Science, Providance University, Taichung, Taiwan.
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