| Higher micronutrient intake is associated with human papillomavirus-positive head and neck cancer: a case-only analysis. | |
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MedLine Citation:
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PMID: 21667401 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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No studies have investigated dietary differences between head and neck squamous cell carcinoma (HNSCC) patients with human papillomavirus (HPV)-positive tumors and patients with HPV-negative tumors. This study was designed to investigate the relationship between diet and HPV status in HNSCC patients. Cases of HNSCC were recruited from 2 clinical centers participating in the University of Michigan Head and Neck Specialized Program of Research Excellence (SPORE). HPV tissue genotyping was performed, and epidemiological and dietary data collected. Multivariable logistic regression tested whether pretreatment consumption of 12 selected micronutrients was significantly associated with HPV-positive status in 143 patients newly diagnosed with cancer of the oral cavity or pharynx. After controlling for age, sex, body mass index, tumor site, cancer stage, problem drinking, smoking, and energy intake, significant and positive associations were observed between vitamin A, vitamin E, iron, β-carotene, and folate intake and HPV-positive status (P(trend) < 0.05), suggesting that diet may be a factor in the improved prognosis documented in those with HPV-positive HNSCC. Dietary differences by HPV status should be considered in prognostic studies to better understand the influence of diet on HNSCC survival. |
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Authors:
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Anna E Arthur; Sonia A Duffy; Gloria I Sanchez; Stephen B Gruber; Jeffrey E Terrell; James R Hebert; Emily Light; Carol R Bradford; Nisha J D'Silva; Thomas E Carey; Gregory T Wolf; Karen E Peterson; Laura S Rozek |
Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural Date: 2011-06-11 |
Journal Detail:
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Title: Nutrition and cancer Volume: 63 ISSN: 1532-7914 ISO Abbreviation: Nutr Cancer Publication Date: 2011 |
Date Detail:
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Created Date: 2011-07-19 Completed Date: 2011-12-12 Revised Date: 2012-01-12 |
Medline Journal Info:
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Nlm Unique ID: 7905040 Medline TA: Nutr Cancer Country: England |
Other Details:
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Languages: eng Pagination: 734-42 Citation Subset: IM |
Affiliation:
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Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109-2029, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Carcinoma, Squamous Cell / diagnosis, etiology*, virology* Cross-Sectional Studies Diet / adverse effects Disease Susceptibility Female Genotype Head and Neck Neoplasms / diagnosis, etiology*, virology* Hospitals, University Hospitals, Veterans Humans Male Michigan Micronutrients / administration & dosage*, adverse effects Middle Aged Papillomaviridae / genetics, isolation & purification* Prognosis Questionnaires |
| Grant Support | |
ID/Acronym/Agency:
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CA097248/CA/NCI NIH HHS; K05 CA136975/CA/NCI NIH HHS; K05 CA136975-03/CA/NCI NIH HHS; R01 DE019126-04/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Micronutrients |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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