Document Detail

Higher maternal plasma folate but not vitamin B-12 concentrations during pregnancy are associated with better cognitive function scores in 9- to 10- year-old children in South India.
MedLine Citation:
PMID:  20335637     Owner:  NLM     Status:  MEDLINE    
Folate and vitamin B-12 are essential for normal brain development. Few studies have examined the relationship of maternal folate and vitamin B-12 status during pregnancy and offspring cognitive function. To test the hypothesis that lower maternal plasma folate and vitamin B-12 concentrations and higher plasma homocysteine concentrations during pregnancy are associated with poorer neurodevelopment, 536 children (aged 9-10 y) from the Mysore Parthenon birth cohort underwent cognitive function assessment during 2007-2008 using 3 core tests from the Kaufman Assessment Battery, and additional tests measuring learning, long-term storage/retrieval, attention and concentration, and visuo-spatial and verbal abilities. Maternal folate, vitamin B-12, and homocysteine concentrations were measured at 30 +/- 2 wk gestation. During pregnancy, 4% of mothers had low folate concentrations (<7 nmol/L), 42.5% had low vitamin B-12 concentrations (<150 pmol/L), and 3% had hyperhomocysteinemia (>10 micromol/L). The children's cognitive test scores increased by 0.1-0.2 SD per SD increase across the entire range of maternal folate concentrations (P < 0.001 for all), with no apparent associations at the deficiency level. The associations with learning, long-term storage/retrieval, visuo-spatial ability, attention, and concentration were independent of the parents' education, socioeconomic status, religion, and the child's sex, age, current size, and folate and vitamin B-12 concentrations. There were no consistent associations of maternal vitamin B-12 and homocysteine concentrations with childhood cognitive performance. In this Indian population, higher maternal folate, but not vitamin B-12, concentrations during pregnancy predicted better childhood cognitive ability. It also suggests that, in terms of neurodevelopment, the concentration used to define folate deficiency may be set too low.
Sargoor R Veena; Ghattu V Krishnaveni; Krishnamachari Srinivasan; Andrew K Wills; Sumithra Muthayya; Anura V Kurpad; Chittaranjan S Yajnik; Caroline H D Fall
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-24
Journal Detail:
Title:  The Journal of nutrition     Volume:  140     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-21     Completed Date:  2010-05-04     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1014-22     Citation Subset:  IM    
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MeSH Terms
Brain / drug effects*,  embryology
Cognition / drug effects*
Cohort Studies
Folic Acid / blood*
Folic Acid Deficiency / blood,  complications,  epidemiology
Hyperhomocysteinemia / blood,  epidemiology
India / epidemiology
Neurogenesis / drug effects*
Nutritional Status
Prenatal Nutritional Physiological Phenomena*
Vitamin B 12 / blood*
Vitamin B 12 Deficiency / blood,  complications,  epidemiology
Young Adult
Grant Support
079877//Wellcome Trust; 079877/Z/06/Z//Wellcome Trust; G0400519//Medical Research Council; MC_U147585821//Medical Research Council; MC_UP_A620_1016//Medical Research Council
Reg. No./Substance:
935E97BOY8/Folic Acid; P6YC3EG204/Vitamin B 12

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