| Higher maternal plasma folate but not vitamin B-12 concentrations during pregnancy are associated with better cognitive function scores in 9- to 10- year-old children in South India. | |
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MedLine Citation:
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PMID: 20335637 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Folate and vitamin B-12 are essential for normal brain development. Few studies have examined the relationship of maternal folate and vitamin B-12 status during pregnancy and offspring cognitive function. To test the hypothesis that lower maternal plasma folate and vitamin B-12 concentrations and higher plasma homocysteine concentrations during pregnancy are associated with poorer neurodevelopment, 536 children (aged 9-10 y) from the Mysore Parthenon birth cohort underwent cognitive function assessment during 2007-2008 using 3 core tests from the Kaufman Assessment Battery, and additional tests measuring learning, long-term storage/retrieval, attention and concentration, and visuo-spatial and verbal abilities. Maternal folate, vitamin B-12, and homocysteine concentrations were measured at 30 +/- 2 wk gestation. During pregnancy, 4% of mothers had low folate concentrations (<7 nmol/L), 42.5% had low vitamin B-12 concentrations (<150 pmol/L), and 3% had hyperhomocysteinemia (>10 micromol/L). The children's cognitive test scores increased by 0.1-0.2 SD per SD increase across the entire range of maternal folate concentrations (P < 0.001 for all), with no apparent associations at the deficiency level. The associations with learning, long-term storage/retrieval, visuo-spatial ability, attention, and concentration were independent of the parents' education, socioeconomic status, religion, and the child's sex, age, current size, and folate and vitamin B-12 concentrations. There were no consistent associations of maternal vitamin B-12 and homocysteine concentrations with childhood cognitive performance. In this Indian population, higher maternal folate, but not vitamin B-12, concentrations during pregnancy predicted better childhood cognitive ability. It also suggests that, in terms of neurodevelopment, the concentration used to define folate deficiency may be set too low. |
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Authors:
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Sargoor R Veena; Ghattu V Krishnaveni; Krishnamachari Srinivasan; Andrew K Wills; Sumithra Muthayya; Anura V Kurpad; Chittaranjan S Yajnik; Caroline H D Fall |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-24 |
Journal Detail:
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Title: The Journal of nutrition Volume: 140 ISSN: 1541-6100 ISO Abbreviation: J. Nutr. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-21 Completed Date: 2010-05-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1014-22 Citation Subset: IM |
Affiliation:
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Epidemiology Research Unit, Holdsworth Memorial Hospital, Mysore 570 021, South India. veenasr@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain / drug effects*, embryology Child Cognition / drug effects* Cohort Studies Female Folic Acid / blood* Folic Acid Deficiency / blood, complications, epidemiology Humans Hyperhomocysteinemia / blood, epidemiology India / epidemiology Male Neurogenesis / drug effects* Nutritional Status Pregnancy Prenatal Nutritional Physiological Phenomena* Vitamin B 12 / blood* Vitamin B 12 Deficiency / blood, complications, epidemiology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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079877/Z/06/Z//Wellcome Trust; G0400519//Medical Research Council |
| Chemical | |
Reg. No./Substance:
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59-30-3/Folic Acid; 68-19-9/Vitamin B 12 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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