Document Detail

Higher immunoglobulin G antibody levels against cytomegalovirus are associated with incident ischemic heart disease in the population-based EPIC-Norfolk cohort.
MedLine Citation:
PMID:  23045624     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cytomegalovirus (CMV) is associated with ischemic heart disease (IHD) among organ transplant recipients. The relationship between the levels of antibody for CMV with IHD in immunocompetent individuals is uncertain.
METHODS: We measured baseline CMV immunoglobulin G (IgG) levels in 12,574 participants without IHD from the population-based EPIC-Norfolk cohort, aged 40-70 years old at recruitment in 1993-1997. Underlying causes of death or hospitalization until 31 March 2008 were abstracted from death certificates and a database of hospital admissions, respectively.
RESULTS: Of the participants, 58% were seropositive for CMV. After a mean follow-up of 12 years (standard deviation, 2.2 years), 1356 first-time IHD events occurred. After adjustment for classic IHD risk factors, belonging to the highest antibody group was associated with an increased risk of incident IHD, compared with seronegativity (hazard ratio, 1.22; 95% confidence interval, 1.05-1.42). After additional adjustment for measures of social class, inflammation, and possible confounders, this association was unchanged (hazard ratio, 1.21; 95% confidence interval, 1.04-11.41).
CONCLUSIONS: This is the first population study to show that CMV IgG antibody levels are related to incident IHD compared to seronegativity. Studies correlating CMV antibody levels with direct measurements of active infection will be necessary.
Effrossyni Gkrania-Klotsas; Claudia Langenberg; Stephen J Sharp; Robert Luben; Kay-Tee Khaw; Nicholas J Wareham
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-08
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  206     ISSN:  1537-6613     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-21     Completed Date:  2013-01-25     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1897-903     Citation Subset:  AIM; IM    
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MeSH Terms
Antibodies, Viral / blood*
Cytomegalovirus / immunology*
Cytomegalovirus Infections / complications,  epidemiology*
Immunoglobulin G / blood*
Middle Aged
Myocardial Ischemia / complications,  epidemiology*
Grant Support
G0401527//Medical Research Council; G0701652//Medical Research Council; G1000143//Medical Research Council; MC_U106179471//Medical Research Council; //British Heart Foundation; //Cancer Research UK; //Department of Health; //Medical Research Council
Reg. No./Substance:
0/Antibodies, Viral; 0/Immunoglobulin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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