| Higher branched-chain amino acid intake is associated with a lower prevalence of being overweight or obese in middle-aged East Asian and Western adults. | |
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MedLine Citation:
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PMID: 21169225 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Beneficial effects on body weight of supplementation with BCAA, including leucine, isoleucine, and valine, have been observed in animal and human studies. However, population-based studies on dietary BCAA intake and body weight are lacking. The objective of this study was to examine the association between dietary BCAA intake and risk of overweight status/obesity among multi-ethnic populations. The International Study of Macro-/Micronutrients and Blood Pressure is a cross-sectional epidemiological investigation in China, Japan, the UK, and the US. The study cohort included 4429 men and women ages 40-59 y who were free of diabetes. Diet was assessed by 4 multi-pass 24-h recalls; data on nutrients including BCAA were derived from country-specific food tables. Overweight status and obesity were defined as BMI ≥ 25 and BMI ≥ 30 kg/m(2), respectively. Multivariable-adjusted OR of overweight status/obesity and 95% CI by quartiles of BCAA intake were estimated by logistic regression. Mean BCAA intake was 2.6 ± 0.6% energy; intake was significantly lower among Chinese participants and similar among participants from the other 3 countries. Compared with those in the first quartile, the multivariable-adjusted OR (95% CI) of overweight status from the 2nd to 4th quartiles of BCAA intake were 0.97 (0.80-1.17), 0.91 (0.75-1.11), and 0.70 (0.57-0.86), respectively (P-trend < 0.01). BCAA intake and obesity were also inversely associated (P-trend = 0.03). In conclusion, higher dietary BCAA intake is associated with lower prevalence of overweight status/obesity among apparently healthy middle-aged adults from East Asian and Western countries. |
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Authors:
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Li-Qiang Qin; Pengcheng Xun; Deborah Bujnowski; Martha L Daviglus; Linda Van Horn; Jeremiah Stamler; Ka He; |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-12-15 |
Journal Detail:
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Title: The Journal of nutrition Volume: 141 ISSN: 1541-6100 ISO Abbreviation: J. Nutr. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-21 Completed Date: 2011-02-23 Revised Date: 2012-02-01 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 249-54 Citation Subset: IM |
Affiliation:
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Department of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amino Acids, Branched-Chain / administration & dosage, therapeutic use* China / epidemiology Diet* Diet Records Female Great Britain / epidemiology Humans Japan / epidemiology Logistic Models Male Middle Aged Obesity / epidemiology, prevention & control* Odds Ratio Overweight / epidemiology, prevention & control* Prevalence Risk Factors United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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R01HL50490/HL/NHLBI NIH HHS; R21DK073812/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids, Branched-Chain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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