Document Detail


Higher adiponectin levels in patients with Berardinelli-Seip congenital lipodystrophy due to seipin as compared with 1-acylglycerol-3-phosphate-o-acyltransferase-2 deficiency.
MedLine Citation:
PMID:  20097706     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Context: Human lipodystrophies are characterized by loss of adipose tissue, insulin resistance, and metabolic complications. The mechanisms linking fat loss to severe insulin resistance remain unclear. Adipokines may have important roles as intermediary players in metabolism. Objective: We sought to determine the plasma concentrations of leptin and adiponectin in patients with Berardinelli-Seip congenital lipodystrophy (BSCL) harboring mutations in the genes encoding either 1-acylglycerol-3-phosphate-O-acyltransferase-2 (AGPAT2) or BSCL2/seipin, in comparison with patients with other forms of inherited or acquired lipodystrophies or insulin receptor alterations. Design: Leptin and total and high-molecular-weight adiponectin were measured in plasma of 16 BSCL1/AGPAT2 and 19 BSCL2/seipin patients and compared with heterozygous (n = 22) or nonmutated relatives (controls, n = 30); patients with Dunnigan-type partial lipodystrophy due to lamin A/C mutations (n = 23), HIV-related lipodystrophy (n = 124), and insulin receptor dysfunctions caused by mutations or autoantibodies (n = 17). Results: Leptin was dramatically decreased in BSCL patients as compared with other subgroups. Adiponectin was decreased in BSCL as compared with controls and patients with altered insulin receptor but was discrepant between the two BSCL subgroups. Whereas total and high-molecular-weight adiponectin levels were almost undetectable in BSCL1/AGPAT2 patients, higher levels were detected in BSCL2/seipin patients, comparable with those of patients with partial lipodystrophy. Adiponectin greater than 1.6 mg/liter had a 100% negative predictive value for AGPAT2 mutations in inherited lipodystrophies. Conclusions: The presence of circulating adiponectin in BSCL2/seipin patients with near absence of adipose tissue outlines the complexity of adiponectin biology. Use of circulating adiponectin might be helpful to guide the genetic investigations in BSCL.
Authors:
Barbara Antuna-Puente; Emilie Boutet; Corinne Vigouroux; Olivier Lascols; Laurence Slama; Martine Caron-Debarle; Eliane Khallouf; Claire L?vy-Marchal; Jacqueline Capeau; Jean-Philippe Bastard; Jocelyne Magr?
Related Documents :
15930086 - Impact of homozygosity for an amyloidogenic transthyretin mutation on phenotype and lon...
12209976 - Increased risk of grade iv neutropenia after administration of 5-fluorouracil due to a ...
1822356 - Muscle coenzyme q10 in mitochondrial encephalomyopathies.
22044706 - Characteristics of isolated atrial flutter versus atrial flutter combined with atrial f...
17470306 - Evaluation of plasma fibronectine level as a probable indicator for tympanosclerosis.
11794706 - Serum kl-6 levels in patients with pulmonary complications after allogeneic bone marrow...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-22
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  95     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-05     Completed Date:  2010-03-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1463-8     Citation Subset:  AIM; IM    
Affiliation:
Institut National de la Sant? et de la Recherche M?dicale, Unit? 938, University Pierre and Marie Curie, Facult? de M?decine Pierre et Marie Curie, Site Saint-Antoine, 27 Rue Chaligny, 75012 Paris France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
1-Acylglycerol-3-Phosphate O-Acyltransferase / deficiency*
Adiponectin / blood*
Adolescent
Analysis of Variance
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
GTP-Binding Protein gamma Subunits / deficiency*
Humans
Leptin / blood
Lipodystrophy, Congenital Generalized / blood*,  genetics
Male
Statistics, Nonparametric
Chemical
Reg. No./Substance:
0/Adiponectin; 0/BSCL2 protein, human; 0/GTP-Binding Protein gamma Subunits; 0/Leptin; EC 2.3.1.51/1-Acylglycerol-3-Phosphate O-Acyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Anxiety is a better predictor of platelet reactivity in coronary artery disease patients than depres...
Next Document:  Medical and Surgical Treatments for Obesity Have Opposite Effects on Peptide YY and Appetite: A Pros...