| High b-Value q-Space Analyzed Diffusion-Weighted MRI Using 1.5 Tesla Clinical Scanner; Determination of Displacement Parameters in the Brains of Normal versus Multiple Sclerosis and Low-Grade Glioma Subjects. | |
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MedLine Citation:
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PMID: 21447030 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: We aimed to determine the displacement parameters in the brains of normal individuals relative to brain parenchymal abnormalities, such as multiple sclerosis (MS) and low-grade glioma, by q-space imaging (QSI) using 1.5-T magnetic resonance (MR) scanner. MATERIALS AND METHODS: Thirty-five normal, three pathologically proven low-grade glioma, and five MS subjects were imaged by a 1.5-T MR unit for QSI (b-values, 0-12,000 s/mm(2) ). Mean displacement (MD) values in white matter (WM), gray matter (GM), and lateral ventricle (cerebrospinal fluid [CSF]) of normal subjects, plaques, and normal appearing WM (NAWM) of MS subjects and glioma lesions were calculated. Mann-Whitney U test was used for comparison. RESULTS: In normal subjects, MD values were 6.6 ± 0.2, 8.44 ± 0.41, and 17.08 ± 0.80 μm for WM, GM, and CSF, respectively, while those for NAWM and WM plaques in MS, and glioma lesions were significantly higher at 7.0 ± 0.17, 9.3 ± 2.3, and 9.6 ± 0.40 μm, respectively, compared to WM in normal subjects. CONCLUSION: We propose that the relative values of MD obtained by QSI in control and diseased tissues can be useful for diagnosing various WM abnormalities. |
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Authors:
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Zareen Fatima; Utaroh Motosugi; Masaaki Hori; Keiichi Ishigame; Toshiyuki Onodera; Kazuo Yagi; Tsutomu Araki |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-29 |
Journal Detail:
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Title: Journal of neuroimaging : official journal of the American Society of Neuroimaging Volume: - ISSN: 1552-6569 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9102705 Medline TA: J Neuroimaging Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 by the American Society of Neuroimaging. |
Affiliation:
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Department of Radiology, University of Yamanashi, Yamanashi, Japan (ZF, UM, MH, KI, TA); Department of Radiology, School of Medicine, Juntendo University, Tokyo, Japan (MH); and Department of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan (TO, KY). |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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