Document Detail

High viscosity of newborn extracellular matrix is the etiology of erythema toxicum neonatorum: neonatal jaundice?: hyaline membrane disease?
MedLine Citation:
PMID:  2255269     Owner:  NLM     Status:  MEDLINE    
At the time of birth, the fetal ground substance is under the influence of maternal and placental hormones. Hormones are known to exert significant effect on ground substance. The ground substance viscosity that is ideal for intrauterine life is too viscous for the newborn. Sites of minor skin trauma develop swelling, inflammation and pustules. Dilution of tissue fluids causes formation of some of the mediators of inflammation including those responsible for intraepidermal pustule formation. The newborn responds to inflammation with eosinophilic granulocyte. The clinical lesions referred to as erythema toxicum neonatorum are known to localize at pressure sites. The skin lesions correct as maternal and placental hormone influence weakens. The entity occurs in 31 to 72% of white infants. The hormone induced viscosity changes may aid in better understanding some aspects of neonatal physiology; such as jaundice of the neonatal period, the eosinophilic granulocyte inflammatory response of the neonatal period and hyaline membrane disease.
O J Stone
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  33     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1991-01-24     Completed Date:  1991-01-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  15-7     Citation Subset:  IM    
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MeSH Terms
Erythema / etiology*,  physiopathology
Extracellular Matrix / physiology*
Hormones / physiology
Hyaline Membrane Disease / etiology*
Infant, Newborn
Inflammation / etiology,  immunology
Jaundice, Neonatal / etiology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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