| High vesicular monoamine transporter binding in asymptomatic bipolar I disorder: sex differences and cognitive correlates. | |
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MedLine Citation:
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PMID: 11007716 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: It has been hypothesized that anomalies in monoaminergic function underlie some of the manifestations of bipolar disorder. In this study the authors examined the possibility that trait-related abnormalities in the concentration of monoaminergic synaptic terminals may be present in patients with asymptomatic bipolar disorder type I. METHOD: The concentration of a stable presynaptic marker, the vesicular monoamine transporter protein (VMAT2), was quantified with (+)[(11)C]dihydrotetrabenazine (DTBZ) and positron emission tomography. Sixteen asymptomatic patients with bipolar I disorder who had a prior history of mania with psychosis (nine men and seven women) and individually matched healthy subjects were studied. Correlational analyses were conducted to examine the relationship between regional VMAT2 binding, cognitive function, and clinical variables. RESULTS: VMAT2 binding in the thalamus and ventral brainstem of the bipolar patients was higher than that in the comparison subjects. VMAT2 concentrations in these regions correlated with performance on measures of frontal, executive function. In addition, sex differences in VMAT2 binding were detected in the thalamus of the bipolar patients; the male patients had higher binding than the women. No sex differences in binding were observed in the healthy comparison group. CONCLUSIONS: These initial results suggest that higher than normal VMAT2 expression and, by extension, concentration of monoaminergic synaptic terminals, may represent a trait-related abnormality in patients with bipolar I disorder and that male and female patients show different patterns. Also, VMAT2 concentrations may be associated with some of the cognitive deficits encountered in euthymic bipolar disorder. |
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Authors:
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J K Zubieta; P Huguelet; L E Ohl; R A Koeppe; M R Kilbourn; J M Carr; B J Giordani; K A Frey |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of psychiatry Volume: 157 ISSN: 0002-953X ISO Abbreviation: Am J Psychiatry Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2000-10-12 Completed Date: 2000-10-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370512 Medline TA: Am J Psychiatry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1619-28 Citation Subset: AIM; IM |
Affiliation:
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Department of Psychiatry, University of Michigan, Ann Arbor, 48104-1687, USA. zubieta@umich.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers Bipolar Disorder / diagnosis, metabolism*, radionuclide imaging Brain Stem / chemistry Cognition Disorders / diagnosis, metabolism Female Humans Male Membrane Glycoproteins / analysis, metabolism* Membrane Transport Proteins* Neuropeptides* Presynaptic Terminals / chemistry, metabolism Sex Factors Tetrabenazine / analogs & derivatives*, diagnostic use Thalamus / chemistry Tomography, Emission-Computed Vesicular Biogenic Amine Transport Proteins Vesicular Monoamine Transport Proteins |
| Grant Support | |
ID/Acronym/Agency:
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RR-00042/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Membrane Glycoproteins; 0/Membrane Transport Proteins; 0/Neuropeptides; 0/SLC18A2 protein, human; 0/Vesicular Biogenic Amine Transport Proteins; 0/Vesicular Monoamine Transport Proteins; 3466-75-9/dihydrotetrabenazine; 58-46-8/Tetrabenazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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