| High uptake of 14C-labeled D-amino acids by various tumors. | |
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MedLine Citation:
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PMID: 7117746 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As an extension of the previous finding that radioactivity of 14C-labeled D-amino acids after injection is localized preferentially in the tumor and the pancreas of tumor-bearing animals as compared with the corresponding L-amino acids tested, the results of similar uptake experiments using other tumors araa reported here. The present studies show high radioactivity uptake by human colon cancer, human thyroid cancer, and human leiomyosarcoma transplanted into nude mice, and by solid leukemia L1210 and solid sarcoma 180, but not by Morris hepatoma 7316A or 3'-methyl-4-(dimethylamino)azobenzene-induced rat hepatoma. The results suggest the potential utility of 11C-labeled D-amino acids for the detection of some cancers. |
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Authors:
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O Tamemasa; R Goto; A Takeda; K Maruo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gann = Gan Volume: 73 ISSN: 0016-450X ISO Abbreviation: Gann Publication Date: 1982 Feb |
Date Detail:
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Created Date: 1982-12-02 Completed Date: 1982-12-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8214471 Medline TA: Gann Country: JAPAN |
Other Details:
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Languages: eng Pagination: 147-52 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Amino Acids / metabolism* Animals Female Humans Leucine / metabolism Male Mice Mice, Nude Neoplasm Transplantation Neoplasms, Experimental / metabolism* Rats Rats, Inbred BUF Rats, Inbred Strains Stereoisomerism |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 61-90-5/Leucine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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