Document Detail


High and typical 18F-FDG bowel uptake in patients treated with metformin.
MedLine Citation:
PMID:  17786437     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: This prospective and bi-centric study was conducted in order to determine the impact of antidiabetic treatments (AD) on (18)F-FDG bowel uptake in type 2 diabetic patients. METHODS: Fifty-five patients with previously diagnosed and treated type 2 diabetes mellitus (group 1) were divided in two subgroups: AD treatment including metformin (n=32; group 1a) and AD treatment excluding metformin (n=23; group 1b). The 95 patients without diabetes mellitus made up controls (group 2). (18)F-FDG uptake in small intestine and colon was visually graded and semi-quantitatively measured using the maximum standardized uptake value. RESULTS: (18)F-FDG bowel uptake was significantly increased in AD patients (group 1) as compared to controls (group 2) (p<0.001). Bowel uptake was significantly higher in AD patients including metformin (group 1a) as compared to AD patients excluding metformin (group 1b) (p<0.01), whose bowel uptake was not significantly different from controls (group 2). A metformin treatment was predictive of an increased bowel uptake in the small intestine (odds ratio OR=16.9, p<0.0001) and in the colon (OR=95.3, p<0.0001), independently of the other factors considered in the multivariate analysis. Bowel uptake pattern in the patients treated with metformin was typically intense, diffuse and continuous along the bowel, strongly predominant in the colon, in both the digestive wall and lumen. CONCLUSION: This study emphasizes that metformin significantly increases (18)F-FDG uptake in colon and, to a lesser extent, in small intestine. It raises the question of stopping metformin treatment before an (18)F-FDG PET/CT scan is performed for intra-abdominal neoplasic lesion assessment.
Authors:
Eric Gontier; Emmanuelle Fourme; Myriam Wartski; Cyrille Blondet; Gerald Bonardel; Elise Le Stanc; Marina Mantzarides; Herve Foehrenbach; Alain-Paul Pecking; Jean-Louis Alberini
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study     Date:  2007-09-05
Journal Detail:
Title:  European journal of nuclear medicine and molecular imaging     Volume:  35     ISSN:  1619-7089     ISO Abbreviation:  Eur. J. Nucl. Med. Mol. Imaging     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-07     Completed Date:  2009-03-04     Revised Date:  2010-04-12    
Medline Journal Info:
Nlm Unique ID:  101140988     Medline TA:  Eur J Nucl Med Mol Imaging     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  95-9     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, Military Hospital Val-de-Gr?ce, 74, Bd de Port Royal, 75230, Paris, cedex 05, France. gontierweb@hotmail.fr
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MeSH Terms
Descriptor/Qualifier:
Case-Control Studies
Colon / drug effects,  metabolism
Diabetes Mellitus, Type 2 / drug therapy*,  metabolism*
Fluorodeoxyglucose F18 / diagnostic use,  pharmacokinetics*
Humans
Hypoglycemic Agents / pharmacology,  therapeutic use*
Intestine, Small / drug effects,  metabolism
Intestines / drug effects*,  metabolism*
Metformin / pharmacology,  therapeutic use*
Tissue Distribution / drug effects
Chemical
Reg. No./Substance:
0/Hypoglycemic Agents; 63503-12-8/Fluorodeoxyglucose F18; 657-24-9/Metformin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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