Document Detail

High turnover rate of Escherichia coli strains in the intestinal flora of infants in Pakistan.
MedLine Citation:
PMID:  10030708     Owner:  NLM     Status:  MEDLINE    
The Escherichia coli flora of infants in developed countries is dominated by one or a few strains which persist for prolonged periods of time, but no longitudinal studies have been performed in developing countries. To this end, we studied the rectal enterobacterial flora in 22 home-delivered Pakistani infants during their first 6 months of life. Three colonies were isolated and species typed on each of 11 sampling occasions. E. coli isolates were strain typed using electromorphic typing of cytoplasmic enzymes, and their O serogroups were determined. There was a very rapid turnover of enterobacterial strains in the rectal flora of individual infants. On average, 8.5 different E. coli strains were found per infant, and several biotypes of other enterobacteria. Less than 50% of the infants were colonized with E. coli from their mothers, but strains of maternal origin were four times more likely to persists in the infants' flora than other E. coli strains. Enterobacteria other than E. coli were always of non-maternal origin, and Enterobacter cloacae and Klebsiella pneumoniae biotypes recovered from contaminated feeds were later identified in the infants' rectal flora. An early colonization with klebsiella or enterobacter was significantly associated with diarrhoea during the neonatal period, although these bacteria were not likely to be the cause of the disease. The results suggest that poor hygienic conditions result in an unstable and diverse enterobacterial flora, which may influence infant health.
I Adlerberth; F Jalil; B Carlsson; L Mellander; L A Hanson; P Larsson; K Khalil; A E Wold
Related Documents :
7716828 - The incidence of neonatal pneumococcal septicemia in sweden 1991-92. the result of a na...
11864128 - Carriage of group b streptococcus in pregnant women and newborns: a 2-year study at per...
20670228 - Incidence and distribution of pathogens in early-onset neonatal sepsis in the era of an...
21455008 - A seven-year survey of management of coagulase-negative staphylococcal sepsis in the ne...
16682838 - Treatment of post-partum thyrotoxicosis.
19023848 - Perinatal outcomes of normal cotwins in twin pregnancies with one structurally anomalou...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Epidemiology and infection     Volume:  121     ISSN:  0950-2688     ISO Abbreviation:  Epidemiol. Infect.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-03-04     Completed Date:  1999-03-04     Revised Date:  2010-03-03    
Medline Journal Info:
Nlm Unique ID:  8703737     Medline TA:  Epidemiol Infect     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  587-98     Citation Subset:  IM    
Department of Clinical Immunology, University of G?teborg, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Diarrhea / etiology
Enterobacteriaceae / isolation & purification
Escherichia coli / classification,  isolation & purification*
Infant Food / microbiology
Infant, Newborn
Longitudinal Studies
Rectum / microbiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Evaluation of pulsed-field gel electrophoresis of genomic restriction fragments in the discriminatio...
Next Document:  P fimbriae and other adhesins enhance intestinal persistence of Escherichia coli in early infancy.