Document Detail


High turnover rate of Escherichia coli strains in the intestinal flora of infants in Pakistan.
MedLine Citation:
PMID:  10030708     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Escherichia coli flora of infants in developed countries is dominated by one or a few strains which persist for prolonged periods of time, but no longitudinal studies have been performed in developing countries. To this end, we studied the rectal enterobacterial flora in 22 home-delivered Pakistani infants during their first 6 months of life. Three colonies were isolated and species typed on each of 11 sampling occasions. E. coli isolates were strain typed using electromorphic typing of cytoplasmic enzymes, and their O serogroups were determined. There was a very rapid turnover of enterobacterial strains in the rectal flora of individual infants. On average, 8.5 different E. coli strains were found per infant, and several biotypes of other enterobacteria. Less than 50% of the infants were colonized with E. coli from their mothers, but strains of maternal origin were four times more likely to persists in the infants' flora than other E. coli strains. Enterobacteria other than E. coli were always of non-maternal origin, and Enterobacter cloacae and Klebsiella pneumoniae biotypes recovered from contaminated feeds were later identified in the infants' rectal flora. An early colonization with klebsiella or enterobacter was significantly associated with diarrhoea during the neonatal period, although these bacteria were not likely to be the cause of the disease. The results suggest that poor hygienic conditions result in an unstable and diverse enterobacterial flora, which may influence infant health.
Authors:
I Adlerberth; F Jalil; B Carlsson; L Mellander; L A Hanson; P Larsson; K Khalil; A E Wold
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Epidemiology and infection     Volume:  121     ISSN:  0950-2688     ISO Abbreviation:  Epidemiol. Infect.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-03-04     Completed Date:  1999-03-04     Revised Date:  2010-03-03    
Medline Journal Info:
Nlm Unique ID:  8703737     Medline TA:  Epidemiol Infect     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  587-98     Citation Subset:  IM    
Affiliation:
Department of Clinical Immunology, University of G?teborg, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Diarrhea / etiology
Enterobacteriaceae / isolation & purification
Escherichia coli / classification,  isolation & purification*
Female
Humans
Infant
Infant Food / microbiology
Infant, Newborn
Longitudinal Studies
Male
Rectum / microbiology*
Serotyping

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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