Document Detail

High total and free 1,25-dihydroxyvitamin D concentrations in serum of premature infants.
MedLine Citation:
PMID:  2316357     Owner:  NLM     Status:  MEDLINE    
We investigated the relationship between serum total and free 1,25-dihydroxyvitamin D (1,25-OH2D) and the biochemical regulation of 1,25-OH2D production in premature infants. We measured 1,25-OH2D, vitamin D binding protein and related biochemical parameters and calculated the free 1,25-OH2D index in serum of 17 premature infants (birthweight 810-1700 g; gestational age 31-36 weeks) on two different occasions defined by body weight (Study A: 1,750-1,850 g, Study B: 2,100-2,200 g). Dietary calcium (Ca) intake was 1,5 or 2,6 mmol/kg/d, phosphorus (P) intake 1,7 mmol/kg/d and vitamin D intake 1,000 IU/d. Biochemical results were similar in infants with different Ca intakes and all were within reference ranges. Concentrations of vitamin D binding protein (Study A 0.15 +/- 0.03 g/l, Study B 0.14 +/- 0.03 g/l; means +/- SD) were lower, concentrations of 1,25 (OH)2D (Study A 180 +/- 67 pmol/l, Study B 216 +/- 53 pmol/l) were higher, and consequently the free 1,25-OH2D index (Study A 6.6 +/- 2.7, Study B 8.8 +/- 2.6) was 4 to 6 times higher than in previously studied term infants. 1,25-OH2D and the free 1,25-OH2D index increased significantly with age and were not correlated with serum P or parathyroid hormone. The data indicate that in premature infants with normal biochemical parameters of Ca and P metabolism elevated concentrations of 1,25-OH2D signify an increased fraction of free 1,25-OH2D and that increased production of 1,25-OH2D is not due to hypophosphatemia or hyperparathyroidism.
R Schilling; F Haschke; C Schatten; M Schmid; W Woloszczuk; I Steffan; E Schuster
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica Scandinavica     Volume:  79     ISSN:  0001-656X     ISO Abbreviation:  Acta Paediatr Scand     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-04-16     Completed Date:  1990-04-16     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0000211     Medline TA:  Acta Paediatr Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  36-40     Citation Subset:  IM    
Department of Paediatrics, University of Vienna, Austria.
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MeSH Terms
Calcitriol / blood*
Calcium, Dietary / metabolism
Infant, Newborn
Infant, Premature / blood*
Phosphorus / metabolism
Random Allocation
Reg. No./Substance:
0/Calcium, Dietary; 32222-06-3/Calcitriol; 7723-14-0/Phosphorus

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