Document Detail

High titres of serum antinuclear antibodies, mostly directed against nucleolar antigens, are associated with the presence of coronary atherosclerosis.
MedLine Citation:
PMID:  11796395     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Inappropriate inflammation is a key mechanism in the development of atherosclerosis. Antibodies against components of the atherosclerotic lesion, in particular, oxidised low density lipoprotein, have been described. OBJECTIVE: To determine whether a systemic autoimmune response, characterised by the presence of high titres of antinuclear antibodies, is associated with the presence of coronary atherosclerosis. METHODS: Serum was prepared from 40 subjects (aged 53-76) with at least 50% stenoses of three main coronary arteries (TVD subjects), and 30 subjects (aged 48-74) with no evidence of coronary atherosclerosis (NCA subjects) determined by coronary angiography. RESULTS: Antinuclear antibodies (ANA), characterised by immunofluorescent detection of human antibodies bound to HEp-2000 cells, were detected at a titre of at least 1/40 in 28 (70%) of the TVD subjects, but only five (17%) of the NCA patients (odds ratio 11.67 (95% confidence interval (CI) 3.91 to 17.82; p<0.001)). Most ANA positive TVD subjects had a pattern typical of antibodies directed against nucleolar antigens. The antigen has not yet been identified, but several common extractable antigens were excluded. The presence of ANA was not associated with incidence of prior myocardial infarction among the TVD group. CONCLUSION: The presence of ANA, commonly associated with autoimmune diseases, is substantially more prevalent among subjects with severe coronary atherosclerosis than those with normal coronary arteries. This association merits further assessment as a potentially useful indicator of increased risk of coronary heart disease.
D J Grainger; H W L Bethell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  61     ISSN:  0003-4967     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-01-17     Completed Date:  2002-02-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  110-4     Citation Subset:  IM    
Department of Medicine, Box 157, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK.
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MeSH Terms
Antibodies, Antinuclear / blood*
Case-Control Studies
Cell Nucleolus / immunology
Coronary Artery Disease / immunology*
Coronary Stenosis / immunology
Fluorescent Antibody Technique
Middle Aged
Statistics as Topic
Reg. No./Substance:
0/Antibodies, Antinuclear
Comment In:
Ann Rheum Dis. 2002 Nov;61(11):1038; author reply 1038   [PMID:  12379537 ]
Ann Rheum Dis. 2002 Feb;61(2):97-9   [PMID:  11796391 ]

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