| High-throughput screening of brief naturalistic stress-responsive cytokines in university students taking examinations. | |
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MedLine Citation:
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PMID: 20483365 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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This study was designed to prospectively examine the impact of a brief naturalistic stressor (academic examination) on salivary/serum cortisol, measures of anxiety and depressive mood, and 50 circulating immune mediators assessed 7 days before, the first day of, and 2 days after the first term examination period (5 days) among 20 male and 6 female medical students (19.7+/-3.1 years, mean+/-SD). Of 42 serum factors detected, repeated measures ANOVA and Bonferroni post hoc testing indicated that concentrations of macrophage migration inhibitory factor (MIF), monocyte chemoattractant protein (MCP)-3, and beta-nerve growth factor (beta-NGF) were significantly decreased 2 days after finishing examinations, compared with the levels on the first day of examinations (p<0.05) in association with a concomitant post-examination decreases (p<0.05) in anxiety and salivary cortisol levels. In contrast, interleukin (IL)-16 was reciprocally increased between the two time points (p<0.05). However, after correction for multiple comparisons, only changes in MIF were significant (p<0.05/42=0.00119), and MIF levels peaked on the first day of examinations was significantly higher than those measured both 7 days before and 2 days after the examination. The present high-throughput analysis with multiplex cytokine panels reconfirms the impact of brief naturalistic stressors on immune outcomes, and suggests a potential role of MIF in the acute stress response. |
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Authors:
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Sakurako Katsuura; Yoshiko Kamezaki; Kumiko Tominaga; Kiyoshi Masuda; Kensei Nishida; Yuta Yamamoto; Keiko Takeo; Naoko Yamagishi; Toshihito Tanahashi; Tomoko Kawai; Kazuhito Rokutan |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-17 |
Journal Detail:
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Title: International journal of psychophysiology : official journal of the International Organization of Psychophysiology Volume: 77 ISSN: 1872-7697 ISO Abbreviation: Int J Psychophysiol Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8406214 Medline TA: Int J Psychophysiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 135-40 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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