Document Detail

High-throughput screening-based identification and structure-activity relationship-characterization defined (S)-2-(1-aminoisobutyl)-1-(3-chlorobenzyl) benzimidazole as a highly antimycotic agent, non-toxic to cell lines.
MedLine Citation:
PMID:  21711055     Owner:  NLM     Status:  Publisher    
Novel non-toxic (S)-2-aminoalkyl benzimidazole derivatives were found to be effective against Candida spp. at low micromolar concentrations using HTS with infected HeLa cells. A collection of analogues defined the chemical groups relevant for activity. The most active compound was characterized by transcriptional analysis of the response of C. albicans Sc5314. (S)-2-(1-Aminoisobutyl)-1-(3-chlorobenzyl)benzimidazole had a strong impact on membrane biosynthesis. Testing different clinically relevant pathogenic fungi showed the selectivity of the antimycotic activity against Candida species.
Jörg Bauer; Stephan Kinast; Anke Burger-Kentischer; Doris Finkelmeier; Gerald Kleymann; Walid Abu Rayyan; Klaus Schröppel; Anuragh Singh; Günther Jung; Karl-Heinz Wiesmüller; Steffen Rupp; Holger Eickhoff
Related Documents :
12474055 - Profiling genes differentially expressed in ngx6 overexpressed nasopharyngeal carcinoma...
12962305 - Comparative functional analysis of rat tgf-beta1 and xenopus laevis tgf-beta5 promoters...
12446785 - Ash1 protein, an asymmetrically localized transcriptional regulator, controls filamento...
21345205 - Cytotoxicity screening of 23 engineered nanomaterials using a test matrix of ten cell l...
22531115 - Routes to copper zinc tin sulfide cu(2)znsns(4) a potential material for solar cells.
23942085 - Intraspecies variation in cotton border cell production: rhizosphere microbiome implica...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-29
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  -     ISSN:  1520-4804     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines.
Next Document:  Anti-DNA:RNA antibodies and silicon photonic microring resonators: increased sensitivity for multipl...