Document Detail


High throughput 'omics' approaches to assess the effects of phytochemicals in human health studies.
MedLine Citation:
PMID:  18503733     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human health is affected by many factors. Diet and inherited genes play an important role. Food constituents, including secondary metabolites of fruits and vegetables, may interact directly with DNA via methylation and changes in expression profiles (mRNA, proteins) which results in metabolite content changes. Many studies have shown that food constituents may affect human health and the exact knowledge of genotypes and food constituent interactions with both genes and proteins may delay or prevent the onset of diseases. Many high throughput methods have been employed to get some insight into the whole process and several examples of successful research, namely in the field of genomics and transcriptomics, exist. Studies on epigenetics and RNome significance have been launched. Proteomics and metabolomics need to encompass large numbers of experiments and linked data. Due to the nature of the proteins, as well as due to the properties of various metabolites, experimental approaches require the use of comprehensive high throughput methods and a sufficiency of analysed tissue or body fluids. In this contribution, we describe the basic tools currently used in nutrigenomics studies and indicate the general requirements for future technology methodological routings.
Authors:
Jaroslava Ovesná; Ondrej Slabý; Olivier Toussaint; Milan Kodícek; Petr Marsík; Vladimíra Pouchová; Tomás Vanĕk
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The British journal of nutrition     Volume:  99 E Suppl 1     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-27     Completed Date:  2009-01-07     Revised Date:  2009-05-20    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  ES127-34     Citation Subset:  IM    
Affiliation:
Crop Research Institute, Drnovská 507, 161 06 Prague 6, Ruzyne, Czech Republic. ovesna@vurv.cz
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MeSH Terms
Descriptor/Qualifier:
Biological Factors / pharmacology*
Diet*
Food
Gene Expression Regulation / drug effects
Humans
Metabolomics / methods
Nutrigenomics / methods*
Nutritional Physiological Phenomena / genetics*
Proteomics / methods
Chemical
Reg. No./Substance:
0/Biological Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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