Document Detail


High-throughput, fully automated volumetry for prediction of MMSE and CDR decline in mild cognitive impairment.
MedLine Citation:
PMID:  19474571     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Medial temporal lobe (MTL) atrophy is associated with increased risk for conversion to Alzheimer disease, but manual tracing techniques and even semiautomated techniques for volumetric assessment are not practical in the clinical setting. In addition, most studies that examined MTL atrophy in Alzheimer disease have focused only on the hippocampus. It is unknown the extent to which volumes of amygdala and temporal horn of the lateral ventricle predict subsequent clinical decline. This study examined whether measures of hippocampus, amygdala, and temporal horn volume predict clinical decline over the following 6-month period in patients with mild cognitive impairment (MCI). Fully automated volume measurements were performed in 269 MCI patients. Baseline volumes of the hippocampus, amygdala, and temporal horn were evaluated as predictors of change in Mini-mental State Examination and Clinical Dementia Rating Sum of Boxes over a 6-month interval. Fully automated measurements of baseline hippocampus and amygdala volumes correlated with baseline delayed recall scores. Patients with smaller baseline volumes of the hippocampus and amygdala or larger baseline volumes of the temporal horn had more rapid subsequent clinical decline on Mini-mental State Examination and Clinical Dementia Rating Sum of Boxes. Fully automated and rapid measurement of segmental MTL volumes may help clinicians predict clinical decline in MCI patients.
Authors:
Sanja Kovacevic; Michael S Rafii; James B Brewer;
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Alzheimer disease and associated disorders     Volume:  23     ISSN:  1546-4156     ISO Abbreviation:  Alzheimer Dis Assoc Disord     Publication Date:    2009 Apr-Jun
Date Detail:
Created Date:  2009-05-28     Completed Date:  2009-07-23     Revised Date:  2013-11-11    
Medline Journal Info:
Nlm Unique ID:  8704771     Medline TA:  Alzheimer Dis Assoc Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  139-45     Citation Subset:  IM    
Affiliation:
Department of Radiology, University of California, San Diego, La Jolla, CA 92093-094, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alzheimer Disease / diagnosis,  pathology*
Amygdala / pathology
Atrophy / pathology
Brain / pathology
Cognition Disorders / diagnosis,  pathology*
Female
Hippocampus / pathology
Humans
Magnetic Resonance Imaging / statistics & numerical data*
Male
Memory Disorders / diagnosis,  pathology
Middle Aged
Neuropsychological Tests / statistics & numerical data
Predictive Value of Tests
Psychiatric Status Rating Scales / statistics & numerical data
Severity of Illness Index
Temporal Lobe / pathology*
Grant Support
ID/Acronym/Agency:
K23 NS050305/NS/NINDS NIH HHS; K23 NS050305/NS/NINDS NIH HHS; K23 NS050305-05/NS/NINDS NIH HHS; U01 AG024904/AG/NIA NIH HHS
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