| High testosterone levels of ovarian origin affect adrenal steroidogenesis? | |
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MedLine Citation:
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PMID: 1846875 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Androgens of ovarian origin have been suggested to affect adrenal enzymatic activity. To investigate this possibility, the 17-hydroxyprogesterone (17-OH P) and cortisol (F) responses to an ACTH stimulation test (0.25 mg iv, bolus) were evaluated in 10 normal women and in 39 hyperandrogenic women with normal (14 subjects) or high (25 subjects) testosterone (T) levels. The 17-OH P release and the ratio between 17-OH P and F release in response to the ACTH stimulation test were significantly higher (P less than 0.05) in hyperandrogenic women with high T levels than in normal subjects. Eight hyperandrogenic women with high T received intranasal GnRH agonist (Buserelin, 1200 micrograms/day) for 4 weeks, and the 17-OH P and F release in response to the ACTH stimulation was reassessed after agonist treatment. At the end of GnRH agonist administration the mean circulating levels of T were significantly reduced (P less than 0.05). The F response to the ACTH test was not modified by pretreatment with the GnRH agonist. The 17-OH P response to the ACTH stimulation test after the GnRH agonist was unchanged in comparison with control tests, as well as the ratio between 17-OH P and F responses to the ACTH test. These data do not seem to confirm, as previously suggested, that high T levels of ovarian origin affect adrenal steroidogenesis. |
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Authors:
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F Fruzzetti; G B Melis; V Mais; D Beconcini; A M Paoletti; G Cristiani; E Mian; P Fioretti |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 72 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1991-03-14 Completed Date: 1991-03-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 426-31 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Pisa, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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17-alpha-Hydroxyprogesterone Adolescent Adrenal Glands / metabolism* Adrenocorticotropic Hormone / diagnostic use Adult Buserelin / pharmacology, therapeutic use Estradiol / blood Female Follicle Stimulating Hormone / blood Hirsutism / metabolism Humans Hydrocortisone / biosynthesis* Hydroxyprogesterones / metabolism* Luteinizing Hormone / blood Ovary / metabolism* Testosterone / blood* |
| Chemical | |
Reg. No./Substance:
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0/Hydroxyprogesterones; 50-23-7/Hydrocortisone; 50-28-2/Estradiol; 57982-77-1/Buserelin; 58-22-0/Testosterone; 68-96-2/17-alpha-Hydroxyprogesterone; 9002-60-2/Adrenocorticotropic Hormone; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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