| High spontaneous intrachromosomal recombination rates in ataxia-telangiectasia. | |
| | |
MedLine Citation:
|
PMID: 8493577 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Ataxia-telangiectasia (A-T) is an inherited human disease associated with neurologic degeneration, immune dysfunction, and high cancer risk. It has been proposed that the underlying abnormality in A-T is a defect in genetic recombination that interferes with immune gene rearrangements and the repair of DNA damage. Recombination was studied in A-T and control human fibroblast lines by means of two recombination vectors. Unexpectedly, spontaneous intrachromosomal recombination rates were 30 to 200 times higher in A-T fibroblast lines than in normal cells, whereas extrachromosomal recombination frequencies were near normal. Increased recombination is thus a component of genetic instability in A-T and may contribute to the cancer risk seen in A-T patients. |
| | |
Authors:
|
M S Meyn |
Related Documents
:
|
2284597 - Sugar-shaped alkaloids. 16162447 - Cortisol decreases and serotonin and dopamine increase following massage therapy. 12543787 - Systemic reovirus therapy of metastatic cancer in immune-competent mice. 17215077 - Relationship of cellular immunity, cytokines and crp with clinical course in breast can... 17318947 - Nutritional aspects regarding lung cancer chemoprevention. 7763037 - Colorectal cancer after irradiation for cervical cancer--case reports. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Science (New York, N.Y.) Volume: 260 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1993 May |
Date Detail:
|
Created Date: 1993-06-17 Completed Date: 1993-06-17 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1327-30 Citation Subset: IM |
Affiliation:
|
Department of Genetics, Yale University School of Medicine, New Haven, CT 06510. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Ataxia Telangiectasia / genetics* Cell Line Cell Line, Transformed Chromosomes, Human / physiology* Cinnamates* Genetic Complementation Test Genetic Vectors Humans Hygromycin B / analogs & derivatives, pharmacology Mice Mitosis Neomycin / pharmacology Phenotype Recombination, Genetic* |
| Grant Support | |
ID/Acronym/Agency:
|
GM38588/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Cinnamates; 1404-04-2/Neomycin; 31282-04-9/Hygromycin B; 6379-56-2/hygromycin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Protection against vaginal SIV transmission with microencapsulated vaccine.
Next Document: Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein.