Document Detail

High sodium intake modulates left ventricular mass in patients with G expression of +1675 G/A angiotensin II receptor type 2 gene.
MedLine Citation:
PMID:  17620959     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: In patients with hypertension left ventricular hypertrophy (LVH) is associated with genetic variations of the angiotensin type 2 receptor (AT2R). Hypertension and LVH are often aggravated by salt intake. Our objective was to assess the relationship between AT2R gene variation and salt intake and their impact on left ventricular mass (LVM). METHODS AND RESULTS: In 205 subjects with normal or mildly elevated blood pressure, we assessed sodium intake and left ventricular structure and function by echocardiography. Intronic +1,675 G/A polymorphism of the AT2R gene was investigated. A-allele carriers had a greater LVM (P = 0.049) than G-allele carriers. Independent of diet, septal wall thickness was higher in A-allele carriers (P = 0.001). Fractional fibre shortening was greater in A-allele carriers (P = 0.034), and the velocity of circumferential fibre shortening tended to be greater in A-allele carriers (P = 0.057). When the two groups were stratified according to their salt intake, only G-allele carriers displayed a modulating effect of salt intake on LVM. Covariance analysis revealed that there was a trend towards a modulating effect of salt intake on LVM, even after taking blood pressure into account (P = 0.054). CONCLUSION: Our data clearly support the notion that LVM is influenced by AT2R polymorphisms. Furthermore, G-allele carriers in particular appear to be susceptible to a modifying effect of increased salt intake on LVM.
Christian Ott; Stephanie I Titze; Thomas K Schwarz; Reinhold Kreutz; Karl F Hilgers; Bernhard M W Schmidt; Markus P Schlaich; Roland E Schmieder
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  25     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-10     Completed Date:  2007-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  1627-32     Citation Subset:  IM    
Department of Nephrology and Hypertension, University of Erlangen-Nuremberg, Nuremberg, Germany.
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MeSH Terms
Blood Pressure / genetics
Heterozygote Detection
Hypertrophy, Left Ventricular / genetics,  pathology*
Receptors, Angiotensin / genetics*
Sodium, Dietary / administration & dosage*
Reg. No./Substance:
0/Receptors, Angiotensin; 0/Sodium, Dietary
Comment In:
J Hypertens. 2007 Aug;25(8):1569-72   [PMID:  17620949 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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