| High serum resistin level may be an indicator of the severity of coronary disease in acute coronary syndrome. | |
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MedLine Citation:
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PMID: 19848317 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the correlation between serum resistin level, cardiovascular risk factors and severity of coronary disease in acute coronary syndrome (ACS). METHODS: After evaluated by clinical history, electrocardiography, exercise tolerance tests, laboratory tests, and coronary angiography, 220 consecutive patients with suspected chest pain were divided into normal control group, stable angina pectoris (SAP) group, and ACS group, respectively. Baseline clinical characteristics, including height, weight, waist circumference, hip circumference, white blood cell count, high-sensitive C-reactive protein (hsCRP), total cholesterol, triglyceride, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol, were compared among three groups. ELISA was used to detect serum resistin levels. Pearson's correlation coefficient analysis was used to assess association between resistin and other traditional cardiovascular risk factors. Multinomial logistic regression analyses were used to define the relationship between serum resistin level and SAP or ACS. RESULTS: Serum resistin level in ACS group (1.18+/-0.48 microg/L) was significantly higher than that in normal control and SAP groups (0.49+/-0.40 and 0.66+/-0.40 microg/L; P<0.01). Only in ACS group, increased serum resistin level was significantly correlated with hsCRP (r=0.262, P=0.004) and white blood cell count (r=0.347, P=0.001). Furthermore, serum resistin levels showed a stepwise increase with the number increase of > 50% stenosed coronary vessels. Multinomial logistic regression test demonstrated that serum resistin was a strong risk factor for ACS (OR=29.132, 95 % CI: 10.939-77.581, P<0.001). CONCLUSION: These findings suggested the potential role of resistin in atherosclerosis and especially its involvement in ACS. |
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Authors:
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Hao Wang; De-You Chen; Jian Cao; Zuo-Yun He; Bing-Po Zhu; Min Long |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chinese medical sciences journal = Chung-kuo i hsüeh k'o hsüeh tsa chih / Chinese Academy of Medical Sciences Volume: 24 ISSN: 1001-9294 ISO Abbreviation: Chin. Med. Sci. J. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-10-23 Completed Date: 2009-12-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9112559 Medline TA: Chin Med Sci J Country: China |
Other Details:
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Languages: eng Pagination: 161-6 Citation Subset: IM |
Affiliation:
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Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Coronary Syndrome
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blood*,
pathology,
physiopathology Aged Biological Markers / blood Case-Control Studies Coronary Disease / blood*, pathology, physiopathology Female Humans Male Middle Aged Resistin / blood* Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/RETN protein, human; 0/Resistin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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