Document Detail

High serum levels of thrombospondin-1 in patients with idiopathic interstitial pneumonia.
MedLine Citation:
PMID:  18640828     Owner:  NLM     Status:  MEDLINE    
Thrombospondin-1 (TSP-1), a multifunctional matricellular glycoprotein, can activate transforming growth factor-beta, an important profibrotic cytokine involved in various fibrotic diseases. TSP-1 is expressed in the lung tissue of animal models of bleomycin-induced pulmonary fibrosis and in patients with some interstitial lung diseases. The present study investigated the serum and bronchoalveolar lavage fluid (BALF) levels of TSP-1 in the idiopathic interstitial pneumonias (IIPs) and the relationship between these levels and other clinical factors. The TSP-1 in the serum and BALF were measured in 45 patients with pathologically diagnosed IIPs [22 with usual interstitial pneumonia (UIP), 23 patients with non-specific interstitial pneumonia (NSIP)], as well as in 28 patients with pulmonary sarcoidosis and 15 healthy volunteers using a competitive enzyme immunoassay. The expression and localization of TSP-1 in the lungs were analyzed by immunohistochemical staining. The serum TSP-1 levels were significantly higher in patients with IIPs than in either those with sarcoidosis or the controls. These levels correlated well with those of an angiogenic cytokine vascular endothelial growth factor while correlating inversely with the %VC. Positive immunostaining of TSP-1 was predominantly observed in the regenerated alveolar epithelium and alveolar macrophages in the lung. Our findings suggest that the circulating TSP-1 levels are associated with the presence of interstitial pneumonia, but further studies are required before we can definitively conclude that TSP-1 plays a role in the pathogenesis of these diseases.
Mioko Ide; Hiroshi Ishii; Hiroshi Mukae; Atsuko Iwata; Noriho Sakamoto; Jun-ichi Kadota; Shigeru Kohno
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-21
Journal Detail:
Title:  Respiratory medicine     Volume:  102     ISSN:  1532-3064     ISO Abbreviation:  Respir Med     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-17     Completed Date:  2009-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  1625-30     Citation Subset:  IM    
Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
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MeSH Terms
Biological Markers / metabolism
Bronchoalveolar Lavage Fluid / cytology
Clinical Protocols
Idiopathic Interstitial Pneumonias / metabolism*,  physiopathology
Immunohistochemistry / methods
Lung / cytology,  pathology
Macrophages, Alveolar / metabolism*
Middle Aged
Thrombospondin 1 / blood,  metabolism*
Transforming Growth Factor beta / metabolism*
Young Adult
Reg. No./Substance:
0/Biological Markers; 0/Thrombospondin 1; 0/Transforming Growth Factor beta

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