Document Detail


High serum cholesteryl ester transfer rates and small high-density lipoproteins are associated with young age in patients with acute myocardial infarction.
MedLine Citation:
PMID:  17996559     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Our aim was to characterize cholesteryl ester transfer protein (CETP) activity in the early phase of acute myocardial infarction (MI). BACKGROUND: Cholesteryl ester transfer protein catalyzes the transfer of cholesteryl esters from high-density lipoprotein (HDL) donors to apolipoprotein B-containing lipoprotein acceptors. METHODS: The CETP concentration, lipid profiles, and the rate of cholesteryl ester transfer (CET) from a tracer dose of radiolabeled HDL toward endogenous lipoproteins were determined within 24 h after symptom onset. RESULTS: Among 347 patients with first MI, CETP concentration, triglycerides, and non-HDL-cholesterol increased across tertiles of the CET rate, whereas HDL-cholesterol, HDL, and LDL sizes decreased gradually. Among lipoprotein donors and acceptors, the best predictors of the CET rate were HDL2b and non-HDL-cholesterol, respectively. Mean age at first MI was 8.5 years lower in the patients from the highest CET tertile than in those in the lowest CET tertile. Diagonal stratification according to both non-HDL-cholesterol and HDL2b tertiles revealed that patients in the highest CET group were 18 years younger than patients in the lowest CET group. Parameters of the high CETP mass/high non-HDL-cholesterol/low HDL2b triad were independently associated with the CET rate. CONCLUSIONS: In patients with acute MI, high CET rates are characterized by the presence of the high CETP mass/high non-HDL-cholesterol/low HDL2b triad. The association of high CET rates with young age at first MI lends support to a significant contribution of CETP to the accelerated progression of disease among asymptomatic patients.
Authors:
Marianne Zeller; David Masson; Michel Farnier; Luc Lorgis; Valérie Deckert; Jean-Paul Pais de Barros; Catherine Desrumaux; Pierre Sicard; Jacques Grober; Denis Blache; Philippe Gambert; Luc Rochette; Yves Cottin; Laurent Lagrost
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-29
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  50     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-12     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1948-55     Citation Subset:  AIM; IM    
Affiliation:
Laboratory of Cardiovascular and Experimental Physiopathology and Pharmacology, IFR Santé STIC, Dijon, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Aged, 80 and over
Cholesterol Ester Transfer Proteins / blood*
Female
Humans
Lipoproteins, HDL / blood*
Male
Middle Aged
Myocardial Infarction / blood*,  epidemiology
Prospective Studies
Sex Factors
Chemical
Reg. No./Substance:
0/Cholesterol Ester Transfer Proteins; 0/Lipoproteins, HDL
Comments/Corrections
Comment In:
J Am Coll Cardiol. 2007 Nov 13;50(20):1956-8   [PMID:  17996560 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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