| High sensitivity of human melatonin, alertness, thermoregulation, and heart rate to short wavelength light. | |
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MedLine Citation:
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PMID: 15585546 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Light can elicit acute physiological and alerting responses in humans, the magnitude of which depends on the timing, intensity, and duration of light exposure. Here, we report that the alerting response of light as well as its effects on thermoregulation and heart rate are also wavelength dependent. Exposure to 2 h of monochromatic light at 460 nm in the late evening induced a significantly greater melatonin suppression than occurred with 550-nm monochromatic light, concomitant with a significantly greater alerting response and increased core body temperature and heart rate ( approximately 2.8 x 10(13) photons/cm(2)/sec for each light treatment). Light diminished the distal-proximal skin temperature gradient, a measure of the degree of vasoconstriction, independent of wavelength. Nonclassical ocular photoreceptors with peak sensitivity around 460 nm have been found to regulate circadian rhythm function as measured by melatonin suppression and phase shifting. Our findings-that the sensitivity of the human alerting response to light and its thermoregulatory sequelae are blue-shifted relative to the three-cone visual photopic system-indicate an additional role for these novel photoreceptors in modifying human alertness, thermophysiology, and heart rate. |
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Authors:
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Christian Cajochen; Mirjam Münch; Szymon Kobialka; Kurt Kräuchi; Roland Steiner; Peter Oelhafen; Selim Orgül; Anna Wirz-Justice |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2004-12-07 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 90 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-03-10 Completed Date: 2005-04-12 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 1311-6 Citation Subset: AIM; IM |
Affiliation:
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Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Kleinstr. 27, CH-4025 Basel, Switzerland. christian.cajochen@pukbasel.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Body Temperature Regulation / physiology, radiation effects* Circadian Rhythm / physiology, radiation effects Color Heart Rate / physiology, radiation effects* Humans Light* Male Melatonin / metabolism* Retinal Cone Photoreceptor Cells / physiology Sleep Stages / physiology, radiation effects Wakefulness / physiology, radiation effects* |
| Chemical | |
Reg. No./Substance:
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73-31-4/Melatonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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