Document Detail

High-sensitivity C-reactive protein: an independent risk factor for left ventricular hypertrophy in patients with lupus nephritis.
MedLine Citation:
PMID:  21076530     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the prevalence of left ventricular hypertrophy (LVH) and its associated risk factors in lupus nephritis (LN) patients.
METHODS: 287 LN patients (age: 38.54 ± 13.31, 262 female) were recruited. Echocardiography and serum high-sensitivity C-reactive protein (hs-CRP) were measured. Their relationship was evaluated by univariate correlation analysis and multivariate regression analysis.
RESULTS: The prevalence of LVH in this cohort was 21.25% (n = 61). Serum hs-CRP level was significantly elevated in patients with LVH compared to those without (8.03 (3.22-30.95) versus 3.93 (1.48-9.48) mg/L, P < .01), and correlated with left ventricular mass index (LVMI) (r = 0.314, P = .001). Multivariate regression analysis further confirmed that hs-CRP was an independent risk factor (β = 0.338, P = .002) for LVH in patients with LN.
CONCLUSIONS: Our findings demonstrated that serum hs-CRP level is independently correlated with LVMI and suggested that measurement of hs-CRP may provide important clinical information to investigate LVH in LN patients.
Beili Shi; Zhaohui Ni; Hong Cai; Minfang Zhang; Shan Mou; Qin Wang; Liou Cao; Zanzhe Yu; Yucheng Yan; Jiaqi Qian
Publication Detail:
Type:  Journal Article     Date:  2010-11-07
Journal Detail:
Title:  Journal of biomedicine & biotechnology     Volume:  2010     ISSN:  1110-7251     ISO Abbreviation:  J. Biomed. Biotechnol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-15     Completed Date:  2011-02-22     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101135740     Medline TA:  J Biomed Biotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  373426     Citation Subset:  IM    
Renal Division, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 1630 Dongfang Road, Shanghai 200127, China.
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MeSH Terms
C-Reactive Protein / analysis*
Cohort Studies
Hypertrophy, Left Ventricular / blood*,  epidemiology*,  ultrasonography
Lupus Nephritis / blood*,  epidemiology*
Middle Aged
Multivariate Analysis
Regression Analysis
Risk Factors
Reg. No./Substance:
9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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