Document Detail

High sensitivity C-reactive protein predicts the development of new carotid artery plaques in older persons.
MedLine Citation:
PMID:  20554169     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIM: Previous studies have shown that increased levels of C-reactive protein (CRP) predict cardiovascular events, including stroke, myocardial infarction and death from cardiovascular causes. Previous studies have also shown that increased levels of CRP are strong predictors of the progression of pre-existing carotid artery plaques. However, whether CRP is involved in the development of new plaques, that may or may not be associated with clinical events, in subjects with clean carotid arteries has been scarcely investigated.
METHODS AND RESULTS: 486 "InCHIANTI" Study participants (200 men and 286 women, 72% aged 65 years and over) free from carotid artery plaques at baseline, also underwent carotid artery scan three years later. We tested the association of baseline characteristics, cardiovascular risk factors and inflammatory markers with the development of new carotid artery plaques. Older participants were significantly more likely to develop new plaques. Independent of age, the relative risks of developing new plaques associated with heavy smoking and family history of atherosclerosis were 1.7 (95%CI 1.5-1.9) and 1.9 (95%CI 1.2-3.1), respectively. Participants with high (>3 μg/mL) and moderate (≥1 and ≤3 μg/mL) CRP levels had a relative risk of 2.2 (95%CI 1.9-2.6) and 1.9 (95%CI 1.6-2.3) respectively, when compared with subjects with low (<1 μg/mL) CRP levels. Surprisingly, risk factors such as hypertension, diabetes, dyslipidemia and overweight/obesity were not significant predictors of the development of new carotid artery plaques.
CONCLUSIONS: High CRP levels independently predict the development of new plaques in older persons with carotid arteries free from atherosclerotic lesions.
R Molino-Lova; C Macchi; A M Gori; R Marcucci; P Polcaro; F Cecchi; F Lauretani; S Bandinelli; R Abbate; E Beghi; J M Guralnik; L Ferrucci
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Publication Detail:
Type:  Journal Article     Date:  2010-05-31
Journal Detail:
Title:  Nutrition, metabolism, and cardiovascular diseases : NMCD     Volume:  21     ISSN:  1590-3729     ISO Abbreviation:  Nutr Metab Cardiovasc Dis     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-23     Completed Date:  2012-01-11     Revised Date:  2013-02-08    
Medline Journal Info:
Nlm Unique ID:  9111474     Medline TA:  Nutr Metab Cardiovasc Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  776-82     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Department of Cardiovascular Rehabilitation, Don Gnocchi Foundation, Florence, Italy.
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MeSH Terms
Age Factors
Atherosclerosis / genetics
C-Reactive Protein / analysis*
Cardiovascular Diseases / blood
Carotid Arteries / pathology*
Carotid Stenosis / epidemiology,  pathology*
Cohort Studies
Prospective Studies
Sex Factors
Grant Support
Reg. No./Substance:
9007-41-4/C-Reactive Protein

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