Document Detail


High-sensitivity C-reactive protein measurements in patients with non-arteritic anterior ischaemic optic neuropathy: a clue to the presence of a microinflammatory response.
MedLine Citation:
PMID:  18577187     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To explore the possibility that individuals with non-arteritic anterior ischaemic optic neuropathy (NA-AION) harbour a heightened microinflammatory response compared to carefully matched controls. METHODS: Diagnosis and follow-up were performed by a senior neuro-ophthalmologist (A.K.). The inflammatory biomarkers included white blood cell count, Westergren erythrocyte sedimentation rate (ESR), quantitative fibrinogen as well as high-sensitivity C-reactive protein (hs-CRP). The values of the inflammatory biomarkers of four and five matched controls were compared to patients with NA-AION. RESULTS: We examined 33 NA-AION patients and 151 controls matched for age, gender, body mass index, oral temperature, smoking status and atherothrombotic risk factors. A significantly elevated concentration was noted for hs-CRP (P = 0.021): 3.3 mg/l for NA-AION patients and 2.1 mg/l for controls. Accelerated ESR (18.8 versus 13.5 mm/hr, P = 0.025) was noted in the NA-AION patients. CONCLUSION: Following appropriate matching to apparently healthy controls, patients with NA-AION presented a microinflammatory response, revealed by the presence of increased hs-CRP concentrations and accelerated ESR. The finding, if confirmed in future studies, might shed more light on the eventual pathophysiological processes involved in the disease and pave the way for new therapeutic approaches.
Authors:
Anat Kesler; Dana Irge; Ori Rogowski; Natan Bornstein; Shlomo Berliner; Itzhak Shapira; Shenhar-Tsarfaty Shani; Einor Ben Assayag
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Publication Detail:
Type:  Journal Article     Date:  2008-06-18
Journal Detail:
Title:  Acta ophthalmologica     Volume:  87     ISSN:  1755-3768     ISO Abbreviation:  -     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-18     Completed Date:  2009-07-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101468102     Medline TA:  Acta Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  216-21     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Tel Aviv Sourasky Medical Centre, Tel Aviv University, Israel. kesler@netvision.net.il
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MeSH Terms
Descriptor/Qualifier:
Aged
Blood Sedimentation
C-Reactive Protein / analysis*
Cohort Studies
Female
Follow-Up Studies
Humans
Inflammation / blood,  diagnosis
Male
Middle Aged
Optic Neuropathy, Ischemic / blood*,  diagnosis
Osmolar Concentration
Sensitivity and Specificity
Time Factors
Chemical
Reg. No./Substance:
9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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