Document Detail


High selenium status in individuals exposed to arsenic through coal-burning in Shaanxi (PR of China) modulates antioxidant enzymes, heme oxygenase-1 and DNA damage.
MedLine Citation:
PMID:  20478284     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Although interactions of arsenite and selenite in mammalian organisms have been suggested by literature data, the antioxidant effects and biochemical mechanisms of dietary selenium on human populations exposed to inorganic arsenic are not fully understood. METHODS: Total blood, urine and hair concentrations of arsenic and selenium were determined in all individuals by hydride generation atomic fluorescence spectrometry. The individuals with skin lesions were subsequently classified as "High As group" and "High Se/As group" and controls were classified as "High Se group" and "Control group" according to their blood selenium concentrations. RESULTS: High selenium status was correlated with elevated activities of serum superoxide dismutase, glutathione peroxidase, catalase, and reduced levels of malondialdehyde, and increased RNA and protein expression of heme oxygenase-1 in peripheral blood mononuclear cells (PBMC) of individuals in the high arsenic group. Urinary 8-hydroxy-2'-deoxyguanosine levels were positively associated with blood arsenic, but inversely with blood and hair selenium among individuals with skin lesions, whereas mRNA are protein levels of 8-oxoganine DNA glycosylase 1 in PBMC increased in the "High Se/As group" compared to the "High As group". CONCLUSIONS: Inorganic arsenic exposure is associated with oxidative stress, which may be prevented by high selenium status via its antioxidative activity and detoxification effect possibly through the formation of an arsenic and selenium containing metabolite, the seleno-bis(S-glutathionyl) arsinium ion.
Authors:
Wanli Xue; Zhilun Wang; Qun Chen; Jinghong Chen; Haojie Yang; Senhai Xue
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-15
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  411     ISSN:  1873-3492     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-07-12     Completed Date:  2010-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1312-8     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Affiliation:
Department of Public Health, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi 710061, PR China.
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MeSH Terms
Descriptor/Qualifier:
Antioxidants / metabolism*
Arsenic*
Base Sequence
Blotting, Western
China
Coal*
DNA Damage*
DNA Primers
Deoxyguanosine / analogs & derivatives,  urine
Environmental Exposure*
Heme Oxygenase (Decyclizing) / metabolism*
Humans
Reverse Transcriptase Polymerase Chain Reaction
Selenium / blood*
Chemical
Reg. No./Substance:
0/8-hydroxy-2'-deoxyguanosine; 0/Antioxidants; 0/Coal; 0/DNA Primers; 7440-38-2/Arsenic; 7782-49-2/Selenium; 961-07-9/Deoxyguanosine; EC 1.14.99.3/Heme Oxygenase (Decyclizing)

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