Document Detail


High-salt diet during pregnancy and angiotensin-related cardiac changes.
MedLine Citation:
PMID:  20216089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: High-salt intake has been demonstrated in link to hypertension, and cardiovascular diseases could be programmed in fetal origins. We determined the influence of high-salt diet during pregnancy on the development of the heart.
METHODS: Fetal cardiac structures, cell cycle, renin-angiotensin system (RAS), and epigenetic alternations in the heart following maternal high salt intake during pregnancy were examined.
RESULTS: Following exposure to high salt, disorganized myofibrillae and mitochondria cristae loss were found in the fetus, S-phase for cardiac cells was enhanced, plasma angiotensin II decreased, and cardiac angiotensin II increased in the fetus. Angiotensin II-increased S-phase in the fetal cardiac cells was primarily via AT1 receptor mechanisms. AT2 receptor mRNA and protein in the fetal heart were not affected, whereas AT1 receptor protein, AT1a, and AT1b mRNA were increased. DNA methylation was found at the CpG sites that were related to AT1b receptors in the fetal heart. Cardiac AT1 receptor protein in the adult offspring was also higher following exposure to prenatal high salt.
CONCLUSION: The results suggest a relationship between high-salt diet in pregnancy and developmental changes of the cardiac cells and renin-angiotensin system.
Authors:
Yang Ding; Juanxiu Lv; Caiping Mao; Huiying Zhang; Aiqing Wang; Liyan Zhu; Hui Zhu; Zhice Xu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  28     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-14     Completed Date:  2010-08-16     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  1290-7     Citation Subset:  IM    
Affiliation:
Institute for Fetal Origin-Diseases, First Hospital of Soochow University and Perinatal Biology Center, Soochow University, Suzhou, China.
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MeSH Terms
Descriptor/Qualifier:
Angiotensins / genetics,  physiology*
Animals
Base Sequence
Blotting, Western
Body Weight
Cell Cycle
DNA Methylation
DNA Primers
Energy Intake
Female
Myocardium / pathology*
Polymerase Chain Reaction
Pregnancy
Rats
Rats, Sprague-Dawley
Sodium Chloride, Dietary / administration & dosage*
Grant Support
ID/Acronym/Agency:
HL090920/HL/NHLBI NIH HHS; R01 HL090920/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Angiotensins; 0/DNA Primers; 0/Sodium Chloride, Dietary
Comments/Corrections

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