Document Detail

High risk of malignancy in familial Barrett's esophagus: presentation of one family.
MedLine Citation:
PMID:  18385604     Owner:  NLM     Status:  MEDLINE    
Barrett's esophagus is an acquired condition fundamentally related to the presence of severe and prolonged pathologic acid and biliary gastro-esophageal reflux. However, genetic factors may also play a role in some cases. The aim of this study is to present 3 generations of a Spanish family with the largest number of members so far reported with Barrett's esophagus or esophageal adenocarcinoma. Of the 24 members of this family studied over 3 generations, 6 patients developed esophageal adenocarcinoma, 4 Barrett's esophagus, 6 clinical symptoms of gastro-esophageal reflux disease without Barrett's esophagus, and 8 were asymptomatic. In conclusion, patients with familial Barrett's esophagus get the disease more severely with a high rate of malignancy and, therefore, the endoscopic surveillance should be closer than in cases of nonfamilial Barrett's esophagus.
Vicente Munitiz; Pascual Parrilla; Angeles Ortiz; Luisa F Martinez-de-Haro; Jose Yelamos; Joaquin Molina
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  42     ISSN:  1539-2031     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-22     Completed Date:  2008-10-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  806-9     Citation Subset:  IM    
Department of Surgery, Virgen de la Arrixaca University Hospital, Murcia, Spain.
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MeSH Terms
Adenocarcinoma* / etiology,  genetics
Aged, 80 and over
Barrett Esophagus* / complications,  genetics
Esophageal Neoplasms* / etiology,  genetics
Gastroesophageal Reflux / complications,  genetics
Middle Aged

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