| High-risk localized prostate cancer: role of radical prostatectomy. | |
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MedLine Citation:
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PMID: 20216315 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: The paucity of randomized trials comparing curative management strategies for high-risk prostate cancer makes treatment decisions in this patient population difficult. Although in the past, high-risk patients have primarily been sent for radiation therapy due to concerns that surgery was not likely to be curative and associated with high side-effect profile, there is renewed interest in radical prostatectomy as the primary treatment for high-risk disease. RECENT FINDINGS: Multiple case series have recently been reported that demonstrate the long-term efficacy of radical prostatectomy in a high-risk population with 15-year prostate cancer-specific survival of over 80%. Comparisons of different treatment options using nonrandomized trials demonstrate improved outcomes with surgery compared with watchful waiting or radiation therapy. SUMMARY: Radical prostatectomy is an acceptable treatment alterative, which provides long-term durable disease control for men with high-risk prostate carcinoma. |
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Authors:
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Robert L Grubb; Adam S Kibel |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current opinion in urology Volume: 20 ISSN: 1473-6586 ISO Abbreviation: Curr Opin Urol Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-15 Completed Date: 2010-08-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9200621 Medline TA: Curr Opin Urol Country: United States |
Other Details:
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Languages: eng Pagination: 204-10 Citation Subset: IM |
Affiliation:
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Division of Urology, Department of Surgery, Washington University in St. Louis, St. Louis, MO 63105, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Male Prostatectomy / methods* Prostatic Neoplasms / mortality, surgery* Risk Assessment Survival Rate Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA 112028/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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