| High risk for hyperlipidemia and the metabolic syndrome after an episode of hypertriglyceridemia during 13-cis retinoic acid therapy for acne: a pharmacogenetic study. | |
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MedLine Citation:
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PMID: 11955026 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Administration of 13-cis retinoic acid (isotretinoin) for acne is occasionally accompanied by hyperlipidemia. It is not known why some persons develop this side effect. OBJECTIVE: To determine whether isotretinoin triggers a familial susceptibility to hyperlipidemia and the metabolic syndrome. DESIGN: Cross-sectional comparison. SETTING: University hospital in Lausanne, Switzerland. PARTICIPANTS: 102 persons in whom triglyceride levels increased at least 1.0 mmol/L (> or =89 mg/dL) (hyperresponders) and 100 persons in whom triglyceride levels changed 0.1 mmol/L (< or =9 mg/dL) or less (nonresponders) during isotretinoin therapy for acne. Parents of 71 hyperresponders and 60 nonresponders were also evaluated. MEASUREMENTS: Waist-to-hip ratio; fasting glucose, insulin, and lipid levels; and apoE genotype. RESULTS: Hyperresponders and nonresponders had similar pretreatment body weight and plasma lipid levels. When reevaluated approximately 4 years after completion of isotretinoin therapy, hyperresponders were more likely to have hypertriglyceridemia (triglyceride level > 2.0 mmol/L [>177 mg/dL]; odds ratio [OR], 4.8 [95% CI, 1.6 to 13.8]), hypercholesterolemia (cholesterol level > 6.5 mmol/L [>252 mg/dL]; OR, 9.1 [CI, 1.9 to 43]), truncal obesity (waist-to-hip ratio > 0.90 [OR, 11.0 (CI, 2.0 to 59]), and hyperinsulinemia (insulin-glucose ratio > 7.2; OR, 3.0 [CI, 1.6 to 5.7]). In addition, more hyperresponders had at least one parent with hypertriglyceridemia (OR, 2.6 [CI, 1.2 to 5.7]) or a ratio of total to high-density lipoprotein cholesterol that exceeded 4.0 (OR, 3.5 [CI, 1.5 to 8.0]). Lipid response to isotretinoin was closely associated with the apoE gene. CONCLUSION: Persons who develop hypertriglyceridemia during isotretinoin therapy for acne, as well as their parents, are at increased risk for future hyperlipidemia and the metabolic syndrome. |
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Authors:
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Nicolas Rodondi; Roger Darioli; Albert-Adrien Ramelet; Daniel Hohl; Vincent Lenain; Jean Perdrix; Vincent Wietlisbach; Walter F Riesen; Thomas Walther; Laurent Medinger; Pascal Nicod; Béatrice Desvergne; Vincent Mooser |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of internal medicine Volume: 136 ISSN: 1539-3704 ISO Abbreviation: Ann. Intern. Med. Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-04-16 Completed Date: 2002-05-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372351 Medline TA: Ann Intern Med Country: United States |
Other Details:
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Languages: eng Pagination: 582-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, CHUV University Hospital, University Medical Policlinic, CH-1011 Lausanne, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acne Vulgaris
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blood,
drug therapy Adolescent Adult Apolipoproteins E / genetics Body Weight Cross-Sectional Studies Dermatologic Agents / adverse effects* Female Genetic Predisposition to Disease* Genotype Glucose Tolerance Test Humans Hyperlipidemias / chemically induced*, genetics* Insulin / blood Isotretinoin / adverse effects* Lipids / blood Male Metabolic Syndrome X / genetics* Middle Aged Pharmacogenetics Retrospective Studies Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E; 0/Dermatologic Agents; 0/Lipids; 11061-68-0/Insulin; 4759-48-2/Isotretinoin |
| Comments/Corrections | |
Comment In:
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Arch Dermatol. 2003 Mar;139(3):376-7
[PMID:
12622636
]
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Summary for patients in:
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Ann Intern Med. 2002 Apr 16;136(8):I38
[PMID:
11955046
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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