| High-risk human papilloma virus and cervical intraepithelial neoplasia in women at 2 hospitals in Mexico City | |
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MedLine Citation:
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PMID: 12415953 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the high risk HPV (HR-HPV) association with Cervical Intraepithelial Neoplasia (CIN) in women of two Dysplasia Clinics in Mexico City. MATERIAL AND METHODS: Prolective case-control study was done. Women with and without security affiliation attended in Instituto Mexicano del Seguro Social (Hospital 1) and Hospital General de México (Hospital 2) were included in the study. Cases were women with histopathologic diagnosis of CIN and controls were women with negative dysplasia in cytologic study (Pap). Information was obtained by direct interview. HR-HPV was determined by Hybrid Capture II assay, in cervical samples. Bivariate and logistic regression analysis was done. RESULTS: One hundred and two cases and 192 controls from Hospital 1 and 89 cases and 66 controls from Hospital 2 were included. 83.3% and 77.3% of women from Hospital 1 and 2 respectively were positive to HR-HPV. The association HR-HPV and CIN in Hospital 1 was ORa = 40.6, C.I. 95% = 17-96.8; while in Hospital 2 there was not association. Age was an effect modifier in the HR-HVP and CIN association, in Hospital 1. It was observed a correlation between viral load and CIN degree. CONCLUSIONS: The HR-HPV infection frequency in controls and CIN I was higher than the reported in other studies. Age was a modifier in the HR-HPV association and CIN. In dysplasia clinics without medical referral system of patients is possible to observe similar risk factors to cervical cancer. |
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Authors:
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Dulce Ma Hernández-Hernández; Alejandro García-Carrancá; Miriam C Guido-Jiménez; José Luis González-Sánchez; Fernando Cruz-Talonia; Teresa Apresa-García; Olga A Martínez-Elizondo; Laura Ornelas-Bernal; Isabel Alvarado-Cabrera; Sergio Muñoz |
Publication Detail:
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Type: Comparative Study; English Abstract; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición Volume: 54 ISSN: 0034-8376 ISO Abbreviation: Rev. Invest. Clin. Publication Date: 2002 Jul-Aug |
Date Detail:
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Created Date: 2002-11-05 Completed Date: 2003-01-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421552 Medline TA: Rev Invest Clin Country: Mexico |
Other Details:
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Languages: spa Pagination: 299-306 Citation Subset: IM |
Affiliation:
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Unidad de Investigación Médica en Enfermedades Oncológicas, Servicio de Patología, Hospital de Oncología, CMN Siglo XXI, IMSS. dulcema@servidor.unam.mx |
Vernacular Title:
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Virus de papiloma humano de alto riesgo (VPH-AR) y neoplasia intraepitelial cervical (NIC) en mujeres de dos hospitales de la Ciudad de México. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biopsy Case-Control Studies Cervical Intraepithelial Neoplasia / epidemiology, pathology, virology* DNA Probes, HPV DNA, Viral / isolation & purification Female Hospitals, General Hospitals, Public Humans Mexico / epidemiology Middle Aged Nucleic Acid Hybridization Papillomaviridae / classification, isolation & purification*, pathogenicity Papillomavirus Infections / epidemiology* Prevalence Prospective Studies Questionnaires Reproductive History Risk Factors Urban Population Uterine Cervical Dysplasia / epidemiology, virology Uterine Cervical Neoplasms / epidemiology, pathology, virology* Virulence |
| Chemical | |
Reg. No./Substance:
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0/DNA Probes, HPV; 0/DNA, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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