Document Detail

High risk factors for valvular heart disease from dopamine agonists in patients with Parkinson's disease.
MedLine Citation:
PMID:  19082526     Owner:  NLM     Status:  MEDLINE    
An association between ergot-derived dopamine agonists and asymptomatic valvular heart disease in Parkinson's disease has been established. For safe use of these agonists, it is important to specify those at high risk for valvular heart disease among patients with Parkinson's disease. We performed a nested case-control study of 223 patients with Parkinson's disease. In results of multivariable logistic analyses, use of pergolide, use of cabergoline, age, male sex, and hypertension were independent significant risk factors for left-sided valvular regurgitation. In patients receiving cabergoline or pergolide, elderly (>or=70 years) hypertensive patients had a markedly high risk for valvular regurgitation (odds ratio 94.5) as compared to non-elderly (<70 years) patients without hypertension. The risk of valvular regurgitation caused by pergolide or cabergoline was found to be highly enhanced by comorbid hypertension or aging, suggesting that special attention should be paid when prescribing cabergoline or pergolide for those patients.
Tomoko Oeda; Motoko Masaki; Kenji Yamamoto; Eiji Mizuta; Naoyuki Kitagawa; Tsuyoshi Isono; Satoshi Taniguchi; Kiyoshi Doi; Hitoshi Yaku; Chikao Yutani; Takashi Kawamura; Sadako Kuno; Hideyuki Sawada
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-12-10
Journal Detail:
Title:  Journal of neural transmission (Vienna, Austria : 1996)     Volume:  116     ISSN:  0300-9564     ISO Abbreviation:  J Neural Transm     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-09     Completed Date:  2009-04-30     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  9702341     Medline TA:  J Neural Transm     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  171-8     Citation Subset:  IM    
Clinical Research Center, Utano National Hospital, Kyoto, Japan.
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MeSH Terms
Age Factors
Benzothiazoles / therapeutic use
Bromocriptine / therapeutic use
Case-Control Studies
Dopamine Agonists / adverse effects*
Ergolines / adverse effects*
Heart Valve Diseases / chemically induced*
Hypertension / complications
Parkinson Disease / drug therapy*
Pergolide / adverse effects*
Risk Factors
Reg. No./Substance:
0/Benzothiazoles; 0/Dopamine Agonists; 0/Ergolines; 25614-03-3/Bromocriptine; 66104-22-1/Pergolide; 83619PEU5T/pramipexole; LL60K9J05T/cabergoline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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