Document Detail

High risk for bilateral Warthin tumor in heavy smokers--review of 185 cases.
MedLine Citation:
PMID:  17050316     Owner:  NLM     Status:  MEDLINE    
CONCLUSIONS: We identified smoking as a significant risk factor for multilocular Warthin tumor development. Therefore, we recommend taking history of smoking into account when making the decisions for surgical strategy. OBJECTIVES: Warthin tumor is a common benign neoplasm of the parotid gland. Risk factors for multilocular development have not been defined. PATIENTS AND METHODS: A total of 185 consecutive patients treated for Warthin tumor were included. Charts were reviewed for symptoms, risk factors, and diagnostic and surgical procedures. Patients were followed for facial function and recurrence. Risk factors were evaluated. RESULTS: Overall, in 203 parotid operations, a lateral parotidectomy (77%) was performed in most cases; 94% were primary surgery and 6% were revision surgery. In 89% of patients swelling was the only symptom. Bilateral Warthin tumor was seen in 17% of patients. Of these cases synchronous and metachronous bilateral tumors were observed in 61% and 39%, respectively. The median time period for second contralateral tumor development was 7 years. Postoperative transient facial dysfunction was observed in 31%, which recovered within 3 months in all cases. Evaluation of risk factors revealed that 89% of the subjects were smokers and 66% were heavy smokers. The risk for bilateral Warthin tumors correlated significantly with the amount of nicotine intake (p=0.003).
Jens Peter Klussmann; Claus Wittekindt; Simon Florian Preuss; Abdulrahman Al Attab; Ursula Schroeder; Orlando Guntinas-Lichius
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta oto-laryngologica     Volume:  126     ISSN:  0001-6489     ISO Abbreviation:  Acta Otolaryngol.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-10-19     Completed Date:  2007-02-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370354     Medline TA:  Acta Otolaryngol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1213-7     Citation Subset:  IM    
Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany.
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MeSH Terms
Adenolymphoma / epidemiology,  etiology*,  surgery
Aged, 80 and over
Facial Paralysis / etiology
Follow-Up Studies
Middle Aged
Neoplasms, Multiple Primary / epidemiology,  etiology*,  surgery
Parotid Gland / surgery
Parotid Neoplasms / epidemiology,  etiology*,  surgery
Postoperative Complications / etiology
Retrospective Studies
Risk Factors
Smoking / adverse effects*,  epidemiology
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