| High-resolution timing of cell cycle-regulated gene expression. | |
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MedLine Citation:
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PMID: 17827275 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The eukaryotic cell division cycle depends on an intricate sequence of transcriptional events. Using an algorithm based on maximum-entropy deconvolution, and expression data from a highly synchronized yeast culture, we have timed the peaks of expression of transcriptionally regulated cell cycle genes to an accuracy of 2 min (approximately equal to 1% of the cell cycle time). The set of 1,129 cell cycle-regulated genes was identified by a comprehensive analysis encompassing all available cell cycle yeast data sets. Our results reveal distinct subphases of the cell cycle undetectable by morphological observation, as well as the precise timeline of macromolecular complex assembly during key cell cycle events. |
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Authors:
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Maga Rowicka; Andrzej Kudlicki; Benjamin P Tu; Zbyszek Otwinowski |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-09-07 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 104 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-10-25 Completed Date: 2007-11-27 Revised Date: 2010-09-15 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 16892-7 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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DNA Replication Gene Expression Regulation, Fungal* Genes, Fungal* Genes, cdc* Saccharomyces cerevisiae / cytology*, genetics* Time Factors Transcription, Genetic |
| Grant Support | |
ID/Acronym/Agency:
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GM 74942/GM/NIGMS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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