| High resolution spectroscopic imaging of GABA at 3 Tesla. | |
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MedLine Citation:
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PMID: 21053317 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A spin echo-based MRSI sequence was developed to acquire edited spectra of γ-aminobutyric acid in an entire slice. Water and lipid signals were suppressed by a dual-band presaturation sequence, which included integrated outer volume suppression pulses for additional lipid suppression. Experiments in three normal volunteers were performed at 3 T using a 32-channel head coil. High signal-to-noise ratio spectra and metabolic images of γ-aminobutyric acid were acquired from nominal 4.5 cm(3) voxels (estimated actual voxel size 7.0 cm(3)) in a scan time of 17 min. The sequence is also expected to co-edit homocarnosine and macromolecules, giving a composite γ-aminobutyric acid(+) resonance. The γ-aminobutyric acid(+) to water ratio was measured using a companion water MRSI scan and was found to correlate linearly with the % gray matter (GM) of each voxel (γ-aminobutyric acid(+)/water = (1.5 × GM + 3.2) × 10(-5), R = 0.27), with higher γ-aminobutyric acid(+) levels in gray matter compared with white. In conclusion, high signal-to-noise ratio γ-aminobutyric acid-MRSI is possible at 3 T within clinically feasible scan times. Magn Reson Med, 2010. © 2010 Wiley-Liss, Inc. |
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Authors:
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He Zhu; Richard A E Edden; Ronald Ouwerkerk; Peter B Barker |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-11-4 |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: - ISSN: 1522-2594 ISO Abbreviation: - Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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