Document Detail

High-resolution phase-contrast MRI of aortic and pulmonary blood flow during rest and physical exercise using a MRI compatible bicycle ergometer.
MedLine Citation:
PMID:  20674204     Owner:  NLM     Status:  In-Data-Review    
PURPOSE: To establish high-resolution phase-contrast magnetic resonance imaging (PC-MRI) using a MRI compatible bicycle ergometer to quantify aortic and pulmonary blood flow during resting conditions and exercise.
MATERIALS AND METHODS: In 20 healthy volunteers (mean age, 26.8±5.0 years) high-resolution PC-MRI (mean temporal resolution, 7.4±3.2ms) was performed in the ascending aorta (AA) and main pulmonary artery (PA) during physical rest and three exercise stages: stage 1, no-load operation; stage 2, heart rate increase 40% compared to rest; stage 3, heart rate increase 80% compared to rest. Flow quantification in AA and PA included flow volume (FV), average velocity (AV), peak velocity (PV) and time to PV (TP).
RESULTS: In stage 1 only TP demonstrated a significant change. With progression to stage 2, all parameters altered significantly. Flow measurements during stage 3 evidenced further alterations only of AV and TP regarding both AA and PA. The deviation of the heart rate from the desired target value was significantly higher for stage 3 compared to stage 2, and 15% of the subjects did not reach the desired target heart rate of stage 3 at all.
CONCLUSION: Flow quantification by high-resolution PC-MRI during exercise using a MRI compatible bicycle ergometer is feasible. Medium exercise stages are necessary and sufficient to demonstrate flow alterations in healthy volunteers. PC-MRI ergometry may give insights into aberrant hemodynamic conditions in patients with cardiovascular and pulmonary disease.
Tim Frederik Weber; Hendrik von Tengg-Kobligk; Annette Kopp-Schneider; Julia Ley-Zaporozhan; Hans-Ulrich Kauczor; Sebastian Ley
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Publication Detail:
Type:  Journal Article     Date:  2010-07-31
Journal Detail:
Title:  European journal of radiology     Volume:  80     ISSN:  1872-7727     ISO Abbreviation:  Eur J Radiol     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106411     Medline TA:  Eur J Radiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  103-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Department of Diagnostic and Interventional Radiology, University Medical Center Heidelberg, INF 110, 69120 Heidelberg, Germany; Department of Radiology, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany.
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