Document Detail


High-resolution multifocal pupillographic objective perimetry in glaucoma.
MedLine Citation:
PMID:  20881285     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The recent development of an objective and noninvasive perimetric technique using pupillary responses to sparse multifocal visual stimuli shows promise for the assessment of visual function in glaucoma. This study assesses the sensitivity and specificity of four variants of dichoptic multifocal pupillographic objective perimetry (mfPOP) with a high-resolution, 40-region/field stimulus.
METHODS: Nineteen normal subjects and 17 with open-angle glaucoma were tested with four 4-minute stimulus protocols, presented in eight segments of 30 seconds each. Achromatic multifocal stimuli comprised 40 test regions per eye arranged in a four-ring dartboard layout subtending 60° of visual field. Background luminance was 10 cd/m² with active stimulus regions displaying steady or flickered stimuli at 290 cd/m². Stimulus durations were between 33 and 150 ms, mean intervals between presentations to each test region ranged from 1 to 16 seconds. Fixation was monitored in real time.
RESULTS: Longer mean intervals and durations resulted in better diagnostic performance. Best results were obtained with 150-ms flickered stimuli and a discriminant function that incorporated both amplitude and width of responses: ROC area under the curve 0.86 ± 0.05 (mean ± SE) across all visual field severities, (n = 34) and 1.00 ± 0.00 for moderate and severe fields (n = 10).
CONCLUSIONS: mfPOP produces separate information on response delay and afferent and efferent defects at every point in the field. The diagnostic accuracy of the 40-region, 150-ms stimulus is comparable to that of commonly used subjective perimeters and encourages further investigation of this technique.
Authors:
Corinne F Carle; Andrew C James; Maria Kolic; Yik-Wen Loh; Ted Maddess
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-02-01
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  52     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-02-02     Completed Date:  2011-03-09     Revised Date:  2013-01-09    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  604-10     Citation Subset:  IM    
Affiliation:
ARC (Australian Research Council) Centre of Excellence in Vision Science, Research School of Biology, The Australian National University, Canberra, Australia.
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MeSH Terms
Descriptor/Qualifier:
Female
Glaucoma, Open-Angle / diagnosis*,  physiopathology
Humans
Intraocular Pressure
Male
Middle Aged
Pupil / physiology*
ROC Curve
Sensitivity and Specificity
Tonometry, Ocular
Vision Disorders / diagnosis*,  physiopathology
Visual Field Tests / methods*
Visual Fields*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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