Document Detail

High-resolution molecular imaging via intravital microscopy: illuminating vascular biology in vivo.
MedLine Citation:
PMID:  23135362     Owner:  NLM     Status:  MEDLINE    
Complications of atherosclerosis and thrombosis are leading causes of death worldwide. While experimental investigations have yielded valuable insights into key molecular and cellular phenomena in these diseases of medium- and large-sized vessels, direct visualization of relevant in vivo biological processes has been limited. However, recent developments in molecular imaging technology, specifically fluorescence imaging agents coupled with high-resolution, high-speed intravital microscopy (IVM), are now enabling dynamic and longitudinal investigations into the mechanisms and progression of many vascular diseases. Here we review recent advances in IVM that have provided new in vivo biological insights into atherosclerosis and thrombosis.
Viviany R Taqueti; Farouc A Jaffer
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Integrative biology : quantitative biosciences from nano to macro     Volume:  5     ISSN:  1757-9708     ISO Abbreviation:  Integr Biol (Camb)     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-29     Completed Date:  2013-07-18     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  101478378     Medline TA:  Integr Biol (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  278-90     Citation Subset:  IM    
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MeSH Terms
Atherosclerosis / metabolism*,  pathology*
Blood Vessels / immunology*,  pathology*
Microscopy, Fluorescence / methods
Molecular Imaging / methods*
Thrombosis / immunology*,  pathology*
Grant Support
NIH HL 108229/HL/NHLBI NIH HHS; R01 HL108229/HL/NHLBI NIH HHS; //Howard Hughes Medical Institute

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